Methodology Report
Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development
Table 2
Epitope prediction performance by Vaxitope as measured by AUC values.
| # | MHC allele | Length | AUC | Sensitivity () | Specificity () | Sensitivity () | Specificity () | Sensitivity () | Specificity () |
| 1 | HLA-A0101 | 9 | 0.929 | .854 | .874 | .99 | .709 | 1 | .621 | 2 | HLA-A0201 | 9 | 0.871 | .298 | .956 | .531 | .876 | .792 | .783 | 3 | HLA-A0201 | 10 | 0.913 | .471 | .957 | .789 | .874 | .901 | .773 | 4 | HLA-A0202 | 9 | 0.869 | .309 | .953 | .658 | .875 | .792 | .774 | 5 | HLA-A0202 | 10 | 0.863 | .333 | .949 | .737 | .808 | .891 | .684 | 6 | HLA-A0203 | 9 | 0.874 | .304 | .956 | .659 | .865 | .828 | .769 | 7 | HLA-A0203 | 10 | 0.867 | .317 | .963 | .691 | .827 | .834 | .712 | 8 | HLA-A0206 | 9 | 0.900 | .387 | .961 | .73 | .867 | .881 | .781 | 9 | HLA-A0206 | 10 | 0.916 | .403 | .957 | .775 | .878 | .922 | .782 | 10 | HLA-A0301 | 9 | 0.887 | .445 | .921 | .855 | .803 | .959 | .69 | 11 | HLA-A0301 | 10 | 0.868 | .505 | .9 | .915 | .706 | .988 | .554 | 12 | HLA-A1101 | 9 | 0.863 | .337 | .946 | .672 | .833 | .859 | .71 | 13 | HLA-A1101 | 10 | 0.879 | .461 | .924 | .9 | .742 | .989 | .627 | 14 | HLA-A2402 | 9 | 0.984 | .727 | .985 | .97 | .879 | 1 | .783 | 15 | HLA-A3101 | 9 | 0.912 | .426 | .952 | .813 | .872 | .927 | .752 | 16 | HLA-A3101 | 10 | 0.855 | .419 | .905 | .889 | .711 | .99 | .563 | 17 | HLA-A3301 | 9 | 0.937 | .495 | .959 | .94 | .851 | .989 | .723 | 18 | HLA-A3301 | 10 | 0.905 | .51 | .942 | .905 | .755 | .966 | .619 | 19 | HLA-A6801 | 9 | 0.908 | .406 | .949 | .841 | .841 | .946 | .744 | 20 | HLA-A6801 | 10 | 0.848 | .418 | .9 | .866 | .701 | .973 | .564 | 21 | HLA-A6802 | 9 | 0.918 | .446 | .96 | .801 | .868 | .922 | .757 | 22 | HLA-A6802 | 10 | 0.913 | .452 | .947 | .837 | .825 | .977 | .715 | 23 | HLA-A6901 | 9 | 0.803 | .279 | .895 | .674 | .785 | .837 | .674 | 24 | HLA-B0702 | 9 | 0.963 | .659 | .966 | .962 | .894 | .981 | .849 | 25 | HLA-B1501 | 9 | 0.873 | .514 | .927 | .816 | .765 | .939 | .603 | 26 | HLA-B3501 | 9 | 0.838 | .403 | .927 | .701 | .775 | .834 | .666 | 27 | HLA-B5101 | 9 | 0.978 | .835 | .953 | 1 | .871 | 1 | .824 | 28 | HLA-B5301 | 9 | 0.989 | .84 | .981 | .991 | .896 | 1 | .825 | 29 | HLA-B5801 | 9 | 0.923 | .769 | .933 | .894 | .813 | .952 | .702 | 30 | H-2-Kb | 8 | 0.936 | .753 | .922 | .935 | .744 | .987 | .623 | 31 | H-2-IAd | | 0.928 | .582 | .992 | .705 | .959 | .82 | .926 | 32 | H-2-IEd | — | 0.977 | .903 | 1 | .935 | .935 | .935 | .887 | 33 | H-2-IEg7 | — | 0.998 | .993 | .989 | .993 | .945 | 1 | .893 | 34 | H-2-IEk | — | 0.940 | .775 | .95 | .875 | .9 | .9 | .813 | 35 | HLA-DPB10401 | — | 0.950 | .717 | .978 | .826 | .924 | .913 | .87 | 36 | HLA-DPB10901 | — | 0.978 | .739 | .989 | .891 | .913 | .913 | .859 | 37 | HLA-DR1 | — | 0.923 | .587 | .972 | .781 | .915 | .838 | .834 | 38 | HLA-DR7 | — | 0.990 | .976 | .988 | .976 | .905 | .976 | .845 | 39 | HLA-DRB11101 | — | 0.952 | .732 | .978 | .828 | .914 | .898 | .831 | 40 | HLA-DRB11501 | — | 0.951 | .846 | .981 | .897 | .942 | .91 | .872 |
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Note: means flexible length.
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