Genetic Risk for Recurrent Urinary Tract Infections in Humans: A Systematic Review

Table 4

Methodological quality of each included study. The studies are listed according to their presentation along this review. (CXCR: IL-8 receptor; MyD88:myeloid differentiation primary response gene 88; NA: not applicable; SIGIRR: single immunoglobulin domain-containing IL-1 receptor-related molecule; TLR: Toll-like receptor; TRAM: TIR domain–containing adaptor inducing IFN-β–related adaptor molecule; TRIF: TIR domain-containing adaptor inducing INF-β).

Authors	Gene polymorphism(s)	Protein(s) expression	Ethnicity	Hardy-Weinberg equilibrium	UTI recurrence	Exclusion of urinary tract malformations
Lundstedt et al. [18]	CXCR1	CXCR1	Caucasians	−	+	−
Smithson et al. [20]	CXCR1 [Unavailable controls]	CXCR1, CXCR2	—	NA	+	+
Lundstedt et al. [19]	—	CXCR1	—	NA	+	−
Frendéus et al. [13, 16]	—	CXCR1	—	NA	+	−
Hawn et al. [21]	TLR1, TLR2,TLR4, TLR5, TIRAP	—	Caucasian	+	+	−
Tabel et al. [22]	TLR2	—	Turkish	+	+	−
Karoly et al. [17]	TLR4, HSPA1B	—	Hungarian	+	+	−
Ragnardosttir et al. [23]	TRIF (assessed in a proportion of patients)	TLR4, MyD88, TRIF, TRAM	—	NA	[asymptomatic bacteriurias]	−
Yim et al. [24]	VEGF, TGF-β1	—	Korean	−	−	−