354068.fig.004a
(a)
354068.fig.004b
(b)
Figure 4: Using the Immune Database and Analysis Resource (IEDB, http://www.immuneepitope.org/) [187] the possible CTL epitopes in the sequence of the tandem repeat PDTRPAPGSTAPPAHGVTS were predicted. (a) Using consensus score only the best sequences for each allele are marked together with their score as well as the percentage of MHC class I alleles (secondary axis) for which the respective sequence is the best scoring sequence in the tandem repeat (the lower score indicates stronger binding); (b) A combined score using the ann algorithm for MHC calss I binding prediction, TAP transport and proteasome cleavage prediction is shown. The presentation is similar to (a). Again only the best-scoring sequences for each allele are shown. The higher scores indicate higher probability of presentation.