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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 357106, 19 pages
http://dx.doi.org/10.1155/2010/357106
Review Article

Modulation of Dendritic Cell Responses by Parasites: A Common Strategy to Survive

1Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), 54090 Tlalnepantla, Estado de México, Mexico
2Department of Immunology, Instituto Nacional de Cardiología “Ignacio Chávez”, Secretaria de Salud, Juan Badiano no. 1, Col Sección XVI, 14080 Tlalpan, México D.F., Mexico

Received 21 August 2009; Accepted 18 November 2009

Academic Editor: Abhay R. Satoskar

Copyright © 2010 César A. Terrazas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Parasitic infections are one of the most important causes of morbidity and mortality in our planet and the immune responses triggered by these organisms are critical to determine their outcome. Dendritic cells are key elements for the development of immunity against parasites; they control the responses required to eliminate these pathogens while maintaining host homeostasis. However, there is evidence showing that parasites can influence and regulate dendritic cell function in order to promote a more permissive environment for their survival. In this review we will focus on the strategies protozoan and helminth parasites have developed to interfere with dendritic cell activities as well as in the possible mechanisms involved.