A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis
Figure 1
Safety control tests for pertussis vaccines. (a) Test for toxicity to mouse weight gain. Physiological saline (SA), an inactivated whole-cell pertussis vaccine (RE), or an acellular pertussis vaccine (PV)-administered mice were weighed on 0, 1, 2, 3, 4, and 7 days postadministration. Ten mice in each group were used, and the mean changes in body weight are indicated. (b) Leukocytosis promoting activity of various pertussis vaccines. White blood cell (WBC) counts in peripheral blood were measured 3 days after vaccine administration. Ten mice in each group were used and the mean WBC counts are indicated.
