Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Figure 1

Cohort data used for simulations. 200 replicate datasets were generated for each model. For all of our calculations we used the same overall number of affected individuals and case-parents however the methods differed in how the case and control data were utilized in each individual test (see Materials and Methods). The same number of affected individuals (𝑛=330) and case-parents (𝑛=400) was used under all three methods. For the combined case-control and conditional logistic regression analysis (CC+CLR) and the log-linear analysis using unrelated controls rather than their parents (HD-NPC), we used the genotypes of unrelated controls (𝑛=325, in blue), whereas for the hybrid design using parents of controls in a log-linear framework (HD), we incorporated the genotypic information of the parents of these controls rather than the controls themselves (𝑛=650, in red).