Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia
Figure 2
Type I error rates and power for the maternal association test under mating asymmetry. (a) Type I error rates are given for the Mother versus Null test as a function of departure from mating symmetry, as measured by , under the null model where GC11 = GC12 = GC22 = GM11 = GM12 = GM22 = 1 (Table 2, Model 5). Allele prevalence is set at . (b) Power to detect a maternal effect is shown as a function of departure from mating symmetry, as measured by , for a scenario with multiplicative effects of the mother (Table 2, Model 7). Allele prevalence is set at . MA models (9 mating-type parameters) were used for log-linear regression under the assumption of mating asymmetry. Horizontal reference lines indicate type I error rate of = 0.05 (a) and power = 0.8 (b). HD: hybrid design using parents of controls in a log-linear framework; HD-NPC: log-linear analysis using unrelated controls rather than their parents; CC+CLR: combined case-control and conditional logistic regression analysis.
