Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia
Figure 3
Power of the forward stepwise procedure to detect joint fetomaternal associations. (a) Power for the HD, HD-NPC and CC+CLR methods is shown as a function of allele prevalence for a scenario with mating symmetry and multiplicative effects of both Child and Mother (Table 2, Model 4). (b) Power for HD and HD-NPC is shown as a function of departure from mating symmetry, as measured by , for a scenario with mating asymmetry and multiplicative effects of both Child and Mother (Table 2, Model 8). Allele prevalence is set at . MA models (9 mating-type parameters) were used for log-linear regression under the assumption of mating asymmetry. Horizontal reference lines indicate power = 0.8. HD, hybrid design using parents of controls in a log-linear framework; HD-NPC: log-linear analysis using unrelated controls rather than their parents; CC+CLR: combined case-control and conditional logistic regression analysis.
