Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Figure 5

Power of HD and HD-NPC to detect mating asymmetry. Power is shown as a function of departure from mating symmetry, as measured by Δ𝐶, under the null model where GC₁₁ = GC₁₂ = GC₂₂ = GM₁₁ = GM₁₂ = GM₂₂ = 1 (Table 2, Model 5). Allele prevalence is set at 𝑞=0.3. Mating asymmetry was evaluated in the log-linear framework using a 3 degree-of-freedom likelihood-ratio test comparing the 9 mating-type parameter model under MA to a 6 mating-type parameter model under MS. Horizontal reference line indicates power = 0.8. HD: hybrid design using parents of controls in a log-linear framework; HD-NPC: log-linear analysis using unrelated controls rather than their parents.