Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia

Table 4

Genes and DNA variants genotyped in the pre-B ALL association study.

Gene (Chromosme)	DNA variant	Position	MAF
CCND1 (11q13)
	rs1944129	69,163,116	0.4876
	rs36225395	69,163,517	0.4523
CDC25a (3p21)
	rs1903061	48,206,923	0.1028
CDKN1A (6p21)
	rs733590	36,753,181	0.3616
	rs762624	36,753,566	0.2714
	rs2395655	36,753,674	0.3968
CDKN1B (12p13)
	rs3759217	12,759,719	0.1159
	rs35756741	12,759,968	0.0865
	rs36228499	12,761,203	0.4342
CDKN2A (9p21)
	rs36228834	21,965,319	0.0512
CDKN2B (9p21)
	rs36229158	22,000,681	0.0282
	rs2069416	22,000,004	0.3742/0.0271
	rs2069418	21,999,698	0.4272
E2F1 (20q11)
	rs3213141	31,738,041	0.2405
HDAC1 (1p35)
	rs1741981	32,529,026	0.3302
	rs36212121	32,529,102	0.0031
	rs36212119	32,529,840	0.0846
MADH3 (15q22)
	rs36221701	65,143,543	0.1199
	rs36222034	65,144,732	0.1111
	rs11633026	65,144,812	0.1235
MDM2 (12q15)
	rs1144944	67,486,752	0.4954
	rs3730485	67,487,073–67,487,112	0.4052
	rs937282	67,488,064	0.483
	rs2279744	67,488,847	0.3662
RB1 (13q14)
	rs1573601	47,774,358	0.2484
TGFB1 (19q13)
	rs2317130	46,553,514	0.3141
	rs4803457	46,553,199	0.3937
	rs11466313	46,553,177–46,553,178	0.3096
	rs1800469	46,552,136	0.3127

DNA variant positions relative to dbSNP build 130. MAF indicates minor allele frequency and was calculated on a control cohort consisting of 329 healthy individuals of European descent.