Research Article
Detection of Fetomaternal Genotype Associations in Early-Onset Disorders: Evaluation of Different Methods and Their Application to Childhood Leukemia
Table 5
Distribution of CDKN2A rs36228834 and CDKN2B rs36229158 genotypes and associated risk estimates for pre-B ALL susceptibility among children.
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Percentages indicate number of individuals with a given genotype/total number of genotyped individuals. Risk estimation was performed using log-linear regression analysis as implemented in the LEM software. Child odd ratios were measured using regression models consisting of the child genotype effect only (Child versus Null) or both child and mother genotypes (Child + Mother versus Null). Mating symmetry (i.e., six mating-type parameters) was assumed at both loci. values of the Wald test provided by LEM are shown for either the 2 degree-of-freedom (2 child genotype effects) or 1 degree-of-freedom (1 child genotype effect resulting from the collapsed heterozygous/homozygous rare genotypes) tests. OR indicates odds ratio; CI: confidence interval. |