Table 2: Molecular networks constituted by the predicted miRNA targets. IPA analysis was performed in order to identify the molecular pathways and functions to which the predicted targets of the differentially expressed miRNAs belong. The networks are generated on the basis of the published literature and ranked by the 𝑃 -value calculated by Fisher’s exact Test. The biological processes in which the targets are involved are determined by IPA using the GOstat application 𝑃 < . 0 1 .

IDMolecules in network 𝑃 -valueFocus moleculesTop functions

1ACTR1A, ADM, APP, BICD2, CABP7, CELSR1, CPSF6, DAG1, ELAVL1, EPHA2, GCH1, GNA13, HIRA, HLX, HNRNPH1, HNRNPM, IFNG, IRF2, KHDRBS1, LARGE, MAPT, MTMR3, MTMR4, MYH9, PCSK2, PLCG1, PTGS2, RASA1, SBF1, SOCS1, SOCS2, STAT6, TNPO1, TNPO2, TRIB210E−2135Cellular Development, Skeletal and Muscular Disorders, Organismal Development

2AEBP2, ATAD2, C1QTNF6, CAV1, CAV2, CBX1, CCND1, CREB1, DAB2IP, DDIT4, DNMT1, DNMT3A, DNMT3B, DUSP9, EED, ESR1, EZH2, FOLR1, HSPA13, KAT2B, LEP, MED1, MED14, NCOA2, NCOA3, NCOA4, NOTCH3, PHF1, PNRC1, PRLR, RBBP7, RBM9, SIRT1, THRA (includes EG:7067), TMOD110E−2135Gene Expression, Cellular Growth and Proliferation, Developmental Disorder

3AKAP13, BCL2L11, CCNE2, CDK6, CDKN1A, CDKN1B, CTGF, CTSB, CUGBP1, DUSP1, E2F1, ESRRG, ETS1, FHL2, FLI1, FOXO1, FOXO3, FOXO4, IGFBP3, IP6K3, JAG1, KRAS, MCF2, NR3C1, PRKD3, RB1CC1, SGK1, SMAD3, SP1, SPHK2, TCF7L2 (includes EG:6934), TGFBR1, TIMP3, TOPBP1, TSPYL210E−2135Cellular Growth and Proliferation, Cellular Development, Cancer

4ADAM12, BCL2, CITED2, EGLN1, FGF9, FRAP1, GATA3, GNAI2, HIF1A, HSPD1, IGF1R, IKBKB, ITGA9, JUNB, KPNA1, KPNB1, MAP2K3, MAP2K5, MAP3K7, MAP3K7IP2, PIAS3, PPM1B, PRKCE, PTEN, PTPN1, RPS6KB1, SKI, SMAD7, SNAI1, SOCS3, SP2, STAT3, UBR5, WT1, ZEB110E−2135Cellular Growth and Proliferation, Cellular Movement, Cell Cycle

5ANP32A, ATP2A2, CD69, CDK5R1, COL1A1, COL1A2, CREM, DDR1, DLL4, E2F3, EGR1, FBXW7, FLT1, HDAC4, IL2, IL18BP, LPL, NDRG1, NOTCH1, PHC1, PHC2, POLA1, PPARA, RANBP2, RB1, RYBP, SHC1, SP3, SP4, TRAM2 (includes EG:9697), XPO1, YBX1, YY1, ZBTB10, ZBTB7B10E−2135Organismal Injury and Abnormalities, Cardiovascular Disease, Cellular Development
6ARNT, BACH1, BCL2L12, BRCA1, CLOCK, CREBBP, CYP1B1, DDX5, EP300, EPAS1, ERBB4, EREG, GABPA, GADD45A, HBEGF, HOXA13, HOXB6, LEF1, MAB21L1, MAX, NCAM1, NFYA, NPAS2, OXTR, PIN1, PPARG, PPP2CA, PTGER4, RBBP8 (includes EG:5932), RUNX1, SDC1, SLC1A2, TGFA, TRERF1, WNT5A10E−2135Gene Expression, Cancer, Genetic Disorder

7ACTB, ARID1A, ARID1B, ARID4A, ARID4B, BTG2, CLIP1, DR1, ETS2, EWSR1, GTF2B, HOXA9, PFN1, RARB, RBL1, RBL2, SAP30, SAP130, SFPQ, SIN3A, SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2 (includes EG:6601), SNIP1, SUMO1, TACC2, TAF4, TAF5, TAF12, TBP, TDG, TOP1, XPO610E−2135Gene Expression, Cellular Assembly and Organization, Cellular Compromise

8ARHGDIA, BTRC, CASP3, CD4, CDC42, CLTC, CTTN, CXCL12, DIABLO, ELK1, ELK3, EZR, F3, FOS, FOSB, GLI3, GSK3B, HNRNPA1, HNRNPC, IL1A, ITPR1, JUND, MAP1B, MCL1, OCRL, PAK1, PGM1, PRKCI, PRKD1, PTX3, RABEP1, RAC1, SEMA3A, SRF, STK410E−2135Cell Death, Cancer, Cellular Assembly and Organization

9CD47, CSF1, CSF1R, CSK, EPHA4, FASLG, FGF1, FN1, FOXP1, GRB2, IRS2, ITGA5, ITGA6, ITGA10, ITGA11, ITGAV, ITGB1, ITGB3, JAK2, KCNA3, MAP2K1, MAP2K4, MAPK1, MET, MITF, NFAT5, PDGFB, PDGFRB, PLXNB1, RAB21, SERPINE1, TNFRSF1A, TNFSF11, TRIB1, YES110E−2135Cellular Growth and Proliferation, Cell-mediated Immune Response, Cellular Movement

10ACTR3, AR, ARHGEF7, ASAP1, CRKL, DYRK1A, ESR1, GDI1, KLF2, LMOD1, LRRK1, MRAS, NCK1, PFTK1, PLS3, POMT2, TEAD3, TRIP10, WAS, WEE1, WIPF1, ZMIZ110E−919Cellular Assembly and Organization, Skeletal and Muscular System Development and Function, Cancer

11AKAP12, AMOTL2, ARL6IP1, ATM, BRCA1, CDC6, CHEK2, E2F1, FKBP3, HS3ST1, LATS2, LBR, MBNL2, MTDH, PPM1D, PPP1R13B, SCN3B, SH3BP4, TP53, TRIO, VCAN10E−717Cancer, Genetic Disorder, Reproductive System Disease

12ANK3, CREB5, DEDD, FRK, GPRC5A, KCNK2, KRT18, MPZL2, MYCBP2, MYO1B, NRK, RAB22A, SPAG9, ZNF21710E−713Cardiovascular Disease, Cellular Development, Cell Morphology
13ADAM19, CADM1, CBFA2T3, CDC42SE1, COL6A3, COL7A1, DAAM1, ERBB2, FN1, HAS3, MFAP2, MPHOSPH9, NET1, PMEPA1, RAP1B, TGFB1, THBS1, THPO, XYLT1, ZFP3610E−716Cancer, Cellular Growth and Proliferation, Dermatological Diseases and Conditions

14ATP1B3, CCND1, COL3A1, COL4A1, COL5A2, CTNNB1, HOXA1, IGF2R, KLF9, LGALS3, M6PR, MAP3K10, NANOG, NPTX1, NRF1, NRIP1, PTPRC, PTTG1, RB1, SPTBN2, TCF7L2 (includes EG:6934), THRB (includes EG:7068), TP5310E−617Organismal Development, Cancer, Cell Cycle

15ALDH1A3, COLQ, DUSP10, EIF4B, GPD2, HSPE1, IL6, IL13, IL1B, MMD, NR4A3, NUAK1, PTPN12, RND3, ROBO1, SEMA3C, SLC7A1, STAC, TNF, TNFSF10, TUB10E−616Small Molecule Biochemistry, Skeletal and Muscular System Development and Function, Cell-To-Cell Signaling and Interaction

16ACSL3, ASXL1, EGR3, JMJD1C, PLK2, PTP4A1, RRM2, RRM1 (includes EG:6240), RRM2B, SEL1L, SFRS3, SLC2A1, SMURF2, SON, STRN3, TNF, TP53, UBE2B, ZFP36L110E−615Nucleic Acid Metabolism, Small Molecule Biochemistry, Genetic Disorder

17CCND1, CCNT1, CCNT2, CDK9, CDKN1A, DNAJB9, FBXW11, GLI1, GLI2, GNAO1, GTF2F2, HSPA5, HTATSF1, ID2, JAG2, MDFIC, MXI1, MYCN, NPM1 (includes EG:4869), POLR2A, POLR2C, RB1, RPS6KA1, RXRA, SFRS1, SUPT5H, SUPT6H, TCERG1, TGFB1, TP53, ULK110E−620Gene Expression, Cellular Development, Cell Cycle

18APBB2, BECN1, CAD, CDKN1A, CFL1, E2F5, ESR1, FANCA, FANCC, FGF7, GFI1, GJA1, GORASP2, HSP90AA1, LIMK1, MAX, MYC, PCBP2, PERP, PTBP1, SPTAN1, TERT, TMSB4X, TP53, XBP110E−517Cell Cycle, Connective Tissue Development and Function, Cellular Compromise

19AP3M1, BCL6, CCND1, CREBL2, ENC1, FOXA1, FTH1, HNF1A, HNMT, MTA3, MUC4, NCOR1, NCOR2, NFE2L2, NFYC, NR5A2, SNX17, SSTR1, TFR2, TFRC, TMOD210E−515Cancer, Gene Expression, Drug Metabolism

20ACTB, ACTL6A, CCNT1, CD9, CTCF, DMAP1, EMD, EPC1, ESR1, HABP2, HNRNPA1, HNRNPF, HNRNPK, HSP90AA1, LEMD3, MKNK2, MORF4L1, MYC, PCBP1 (includes EG:5093), SYNE2, TBP, THOC4, TNPO1, TRRAP, U2AF1, WNT1, WNT2B, YY1, ZBTB3310E−518Gene Expression, Cancer, Reproductive System Disease
21BEX2, CDH1, CDH2, CDH11, CTNNA2, CTNNB1, CTNND2, DIO2, ELAVL1, EPHB3, ERBB2, ESR1, F13A1, HNRNPD, ILF3, IRS1, JUP, KHSRP, LDB1, LMO2, NHLH2, PIK3R1, PKD1, PPP3CA, PTCH1, PTPRF, TCF7L2 (includes EG:6934), TIAL1, TP53, TSC22D1, ZNF34610E−418Cell-To-Cell Signaling and Interaction, Cancer, Cellular Growth and Proliferation

22ACIN1, AP2A1, BRD2, COIL, EIF4A1, EIF4G3, ICMT, LMO7, MAP7, NME1, PA2G4, PABPC1, PABPN1, PAIP1, PAIP2, PAPOLG, PNN, RNGTT, RNPS1, SAP18, SFRS11, TALDO1, TRA2B, ZNF14310E−415RNA Post-Transcriptional Modification, Protein Synthesis, Gene Expression

23ADAM9, ADAM10, BMP7, CCL2, CCL5, CDH1, COL18A1, CTNNB1, DICER1, EGF, EGFR, EPS15, ERBB2, ETV1, GRB2, HGS, IL8, L1CAM, LPAR1, LPP (includes EG:4026), MAP3K14, NKRF, RALA, RELA (includes EG:5970), SHC1, SMAD5, SPG20, SRC, TBK1, TERT, TJP1, TMEM55A, TMEM55B, TNF10E−419Cell-To-Cell Signaling and Interaction, Tissue Development, Cancer

24ALOX15, BZW2, CCL3, CHST2, DHCR24, FCER2, GAS7, GATA6, IGHE, IL4, IL8, IL13, MTSS1, NHLH1, NOS2, NOTCH2, PDGFC, PHLDA1, PLXNC1, RIN2, SORT1, ST8SIA410E−414Genetic Disorder, Inflammatory Disease, Respiratory Disease

25CAND1, CCND2, CDC5L, CDKN1B, CUL1, CUL2, CUL3, DNTT, FBXL3, FBXW2, GPR37, PARK2, PITX2, PLRG1, PMS1, PRCC, PRPF19, PSMA2, PSMC1, PSMC5, RAD23B, RBX1 (includes EG:9978), SFRS2, SKP1, SKP2, TCEB1, VHL10E−416Post-Translational Modification, Cancer, Immunological Disease

26AMOT, B4GALT5, BTG3, CCL2, CD40, CHMP2B, CLASP1, ETS1, F3, FOS, HIVEP1, IKBKB, IL2, IL6, IL15, JAK1, JUN, MAPK1, MAPK14, MVP, NEFM, NFKB1, NFKBIA, PLG, PPP2R1B, RAB32, RELA (includes EG:5970), RFWD2 (includes EG:64326), RGS2, SQSTM1, STAT1, STAT3, TNF, TYK2, ZBTB1110E−419Hematological System Development and Function, Cell Death, Cell Cycle

27CCNA2, CCNB1, CCNE1, CCNE2, CD46, CD59, CDK2, CDKN1C, E2F4, EPHB2, FBXO32, HDAC9, HIVEP2, IGFBP3, KLF4, LATS1, LTC4S, MYB (includes EG:4602), MYBL2, NDC80, NUMB, PCNA, PLAU, POLD1, RALBP1, RBL1, RBL2, RFC4, RFX1, SCD, SPARC, SUZ12, TGFB1, TGFB3, TNS310E−419Cell Cycle, Cancer, Cellular Growth and Proliferation
28ABL1, ADRB2, ATP1A1, ATP1A2, ATP1B1, BCAR1, BCAR3, BCR, CBL, CRK, DOCK1, FRAP1, FYN, GATA2, GRK4, ITGA2B (includes EG:3674), ITGB3, MAPK9, MGRN1, NEU2, PIAS1, PIK3R1, PLSCR1, PRKCD, PTK2, RAPGEF1, RECK, SP3, SRC, STAT1, TIMP2, TP73, TP53INP1, TSG101, VPS2810E−419Cell Death, Cellular Movement, Cellular Growth and Proliferation

29AKAP11, B2M, BHLHE40, CALD1, CEBPA, CHI3L1, COL16A1, EDN1, EDNRB, EIF1AX, EMP1, HMGA1, HMGCR, HMGCS1, IDI1, INSIG1, IPO13, KIT, KITLG, LSS, MMP2, MMP3, NAMPT, NPPB, PRKCA, PTPN6, RETN, SCARB1, SERPINB1, SERPINE1, TGFBR2, TGIF2, TNC, TNF, UBE2I10E−419Cancer, Hematological Disease, Lipid Metabolism

30ALOX12B, APOE, ATF7IP, BCAT2, CAMK2A, CAMK2N1, CCND3, CDKN1B, CHAF1A, CRYBB2, DPP4, EFNA5, ESR1, GSTP1, HBE1, IL4, IL13RA1, IRF4, KCNK10, MBD1, MBD2, MBD3 (includes EG:53615), MECP2, MGMT, NR1H3, NR2F2, PIP5K3, PRLR, PTPN4, PTPRM, SETDB1, SLCO3A1, TFF2, TP53BP2, TSC110E−419Behavior, Reproductive System Development and Function, Neurological Disease

31ARHGEF6, BNIP2, CASP8, CHFR, CPD, CS, ELF1, IFNB1, IL8, IL16, INS, IRF1, JAK2, LMTK2, NCF2, NFKBIA, NGFR, PGAM1, PGK1, PLAGL2, PPP1CC, PPP1R12B, PRL, STAT1, TNF, TRADD10E−315Immunological Disease, Cell Death, Hematological Disease

32ACHE, AGT, APP, ATP2B1, BACE1, BIK, BMP2, BTG2, CCL20, CD40LG, CDH1, CXCL2, CYCS (includes EG:54205), EFNA1, EIF4E, EIF4EBP1, GCLC, ITM2B, JUN, LAMP3, LYN, MYO6, PDK4, PPARD, PSEN1, PTGS2, PXN, SMAD1, SMPD2, SOX9, TNF, TNFAIP2, TNFSF10, TRPV6, VCL10E−318Cell Death, Cancer, Cell-To-Cell Signaling and Interaction

33AHR, ANP32B, ATM, BIRC3, BTG2, CAMK2G, CEBPE, CLU, ELAVL1, ERCC1, GDF11, H2AFX, HDAC3, HNRNPD, HNRNPU, HOXA5, ILF3, NEDD8, NUP153, RAD50, RARA, RARB, RARG, TBX3, TERF2, TERF2IP, TIA1, TIAL1, TINF2, TP53, TPR, XPO1, XRCC5, XRCC6, YAP110E−318Cell Cycle, DNA Replication, Recombination, and Repair, Cell Death
34ADH5 (includes EG:128), ASH2L, ATP6V0C, C16ORF53, CHRNA5, CSNK2A1, CSNK2B, DPY30, EDA, ETV4, HCFC1, HDAC1, HIST2H4A, MIER1, MLL3, MLL4, MRC2, NCOA6, OGT (includes EG:8473), PAXIP1, PKNOX1, PLAU, PLAUR, POU2F1, RBBP5, SIN3A, SP1, SP3, SSRP1, SUB1, SUPT16H, TEAD1, TRIM63, WDR5, ZBTB7A10E−318Gene Expression, Cell Morphology, Reproductive System Development and Function

35APLN, BID, CASP2, CFLAR, CXCL13, CYCS (includes EG:54205), DIABLO, EIF2S1, EIF4B, EIF4E, EIF4EBP1, EIF4G1, IL21, IL1RN, INHA, INHBA, INHBB, JAK1, LEFTY1, MCL1, NFKB2, P4HA1, PPP1R15A (includes EG:23645), PRDM1, SATB1, SERPINB2, SOCS1, SOCS3, SUV39H1, TAL1, TLR4, TNF, TNFSF10, USF1, USF210E−318Protein Synthesis, Cancer, Cell Death

36CEBPB, CSF1, CSF3, EGFR, FGA, GAB1, GRB2, IL6, IL1A, IL6ST, IRS1, JAK1, KIF5B, LIFR, LMO4, LPAR2, MAP2, MED28, NF2, NFKB1, OSM, OSMR, PIK3C2B, PLG, POU2F1, POU2F2, PRL, PTGS2, PTPN11, RNASE1, RNASE2, SKAP2, STAT3, TLR9, VIP10E−318Cellular Development, Cellular Growth and Proliferation, Cancer

37AOF2, BAZ1A, BAZ1B, CACNA1C, CDYL, CHRAC1, CTBP1, CTBP2, EHMT1, EHMT2, GATA4, HAND1, HAND2, HDAC2, HMG20B, KCNJ3, MEF2C, MYOCD, PDS5A, PHF21A, POLE3, RAD21, RBBP4, RCOR1, RREB1, SCN5A, SFRP1, SMARCA1, SMARCA5, SMC3, SMC1A, STAG1, STAG2, WIZ, ZEB210E−318Cell Cycle, DNA Replication, Recombination, and Repair, Gene Expression

38AKAP1, API5, ARHGEF12, CFTR, COL18A1, F2, F2R, FGF2, FGFR1, IL1B, IQGAP2, MPRIP, PPP1R12A, PRKAR2B, PRKG1, PTGER3, RHOA, SH3GLB1, SH3GLB2 (includes EG:56904), SLC9A3R1, SRC, STX1A, VCP10E−313Cellular Assembly and Organization, Cell Morphology, Cancer

39ACVR1, ACVR1B, ACVR2A, ANTXR1, APC, ASAP2, BCAP31, BIN1, BMP2, BMP6, BMP7, BMPR2, BMPR1A, CANX, COL18A1, CTNNB1, DCTN1, EFNB2, ERBB2, F10, ICAM1, ID1, ITGB2, MAPRE 1 , NOG, NRP1, PLP2, SEC23A, TGFB1, TLN1, TNFRSF2110E−316Cell Signaling, Cellular Development, Connective Tissue Development and Function
40ARCN1, BRCA2, BRIP1, COPB1, COPG, CYLD, EXO1, HERC2, KPNA2, KPNB1, MAD2L2, MLH1, MMS19, MSH6, PIK3C2A, PMS1, PMS2, PSD2, PSMC1, RANBP9, REV1, REV3L, RFC2, RUFY1, SACM1L, SBF2, SSB (includes EG:6741), TMED9, UBA52, UBR5, USP510E−215DNA Replication, Recombination, and Repair, Cancer, Gastrointestinal Disease

41CCNB1, CD44, EGFR, EIF3A, ERBB2, ERRFI1, GAB1, IL6ST, JARID1B, KRT7, MYBL2, MYO10, NEDD9, PARP1, PIK3CA, PIK3CD, PIK3R1, PIK3R2, RAB31, SMAD2, SOLH, SOX4, TGFB1, TGIF1, TGOLN2 (includes EG:10618), TNF10E−213Cell Cycle, Cellular Growth and Proliferation, Carbohydrate Metabolism

42ADCYAP1, AMPD3 (includes EG:272), CCL3, CCL4, CCL5, CD40, CD40LG, CSF3, CXCL10, DUSP1, DUSP6, FURIN, IER2, IL3, IL17A (includes EG:3605), IL1B, ITGAM, MAP2K6, MAPK3, MAPK14, MMP9, NAMPT, NFKB2, NGF, NR4A2, NSMAF, P2RX7, PLD1, PLG, PTGFR, SERPINB2, TOB1, TRAF3, TSC22D3, VEGFA10E−216Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking

43ATM, ATR (includes EG:545), C10ORF119, CDC6, CDC37, CDC25A, CDC25B, CHEK1, CHEK2, CSNK1A1, E2F1, FAS, GRB10, MAP3K11, MAP3K5 (includes EG:4217), MCM2, MCM3, MCM4, MCM7, MDM4, PLK1, PPP2R3A (includes EG:5523), PPP5C, RAD17, RAF1, SNAP23, SSH2, STX4, STX6, STX16, TP53, VAMP2, VAMP3, VIM, YWHAB10E−216DNA Replication, Recombination, and Repair, Cancer, Cell Cycle

44BAK1, BAX, BCL2, BCL2L1, BID, BMF, BSG, CAV1, CAV3, CDC2, CDK2, CIT, CYCS (includes EG:54205), DLG4, ECT2, GIT1, GRIN2A, HINT1, HTT, IGFBP5, KIF14, KIF23, KRAS, LRP1, MEOX2, NCL, NCSTN, NT5C3, PLK1, PRC1, PSEN1, PSEN2, RACGAP1, TP53, VDAC210E−215Cell Death, Cell Cycle, Cancer

45ASCL2, ASF1A, ATXN7, CCNH, CDK7, CRIP2, CSPG4, DKK1, ENO3, ERCC2, ERCC3, ESRRA, GK, GPR64, GTF2H1, GTF2H2, HMGN1, MLL2, MNAT1, NR2C2, NT5E, PPARGC1A, RBBP5, SAFB, SMAD6, TAF1, TAF2, TAF4, TAF8, TAF9, TAF11, TAF15, TFF1, TUBB, UTX10E−215Gene Expression, DNA Replication, Recombination, and Repair, Dermatological Diseases and Conditions
46ADAMTS5, BAX, BCL2, BCL2L1, BRCA1, CASP3, CCL3, CCL4, CD226, CD244, CSF2, FLNB, GP9, GP1BA, IL8, IL15, IL18, IL18R1, KLRK1, LCP2, MMP1 (includes EG:4312), MNT, MOAP1, NCR1, PDIA3, RAB9A, SELL, SOD2, TERT, TP63, VDAC1, XRCC6, YWHAE, YWHAQ (includes EG:10971), YWHAZ10E−215Cell-to-Cell Signaling and Interaction, Hematological System Development and Function, Cell Death

47ABCA1, AKT1, APOA1, CCDC88A, CCL2, CCL5, COL2A1, CSH1, CUL5, FKBP1A, FLOT1, IGF1, IL8, IL13, IL1B, IL1RN, ILK, INS, LOX, MMP7, PDE4D, PDPK1, PGF, RNF4, RYR1 (includes EG:6261), SLC2A4, STK38L (includes EG:23012), TNF, TRPS110E−213Cell-mediated Immune Response, Cellular Movement, Lipid Metabolism

48EIF2C1, EIF2C2, TNRC6A10E−23Infection Mechanism, Cancer, Respiratory Disease

49DMD, DTNA, DTNB10E−23Cellular Assembly and Organization, Nervous System Development and Function, Skeletal and Muscular System Development and Function