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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 373426, 5 pages
http://dx.doi.org/10.1155/2010/373426
Research Article

High-Sensitivity C-Reactive Protein: An Independent Risk Factor for Left Ventricular Hypertrophy in Patients with Lupus Nephritis

Renal Division, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China

Received 16 March 2010; Revised 7 July 2010; Accepted 14 October 2010

Academic Editor: J. W. Tervaert

Copyright © 2010 Beili Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To determine the prevalence of left ventricular hypertrophy (LVH) and its associated risk factors in lupus nephritis (LN) patients. Methods. 287 LN patients (age: 38.54 Β± 13.31, 262 female) were recruited. Echocardiography and serum high-sensitivity C-reactive protein (hs-CRP) were measured. Their relationship was evaluated by univariate correlation analysis and multivariate regression analysis. Results. The prevalence of LVH in this cohort was 21.25% ( 𝑛 = 6 1 ). Serum hs-CRP level was significantly elevated in patients with LVH compared to those without (8.03 (3.22–30.95) versus 3.93 (1.48–9.48) mg/L, 𝑃 < . 0 1 ) , and correlated with left ventricular mass index (LVMI) ( π‘Ÿ = 0 . 3 1 4 , 𝑃 = . 0 0 1 ). Multivariate regression analysis further confirmed that hs-CRP was an independent risk factor ( 𝛽 = 0 . 3 3 8 , 𝑃 = . 0 0 2 ) for LVH in patients with LN. Conclusions. Our findings demonstrated that serum hs-CRP level is independently correlated with LVMI and suggested that measurement of hs-CRP may provide important clinical information to investigate LVH in LN patients.