About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 384523, 7 pages
http://dx.doi.org/10.1155/2010/384523
Research Article

Infection with Hymenolepis diminuta Is More Effective than Daily Corticosteroids in Blocking Chemically Induced Colitis in Mice

Gastrointestinal Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe & Joan Snyder Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, AB, Canada T2N 4N1

Received 24 July 2009; Accepted 16 September 2009

Academic Editor: Luis I. Terrazas

Copyright © 2010 Alexandra Melon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-F. Bach, “The effect of infections on susceptibility to autoimmune and allergic diseases,” The New England Journal of Medicine, vol. 347, no. 12, pp. 911–920, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Yazdanbakhsh, P. G. Kremsner, and R. van Ree, “Allergy, parasites and the hygiene hypothesis,” Science, vol. 296, pp. 490–494, 2002.
  3. D. E. Elliott, J. F. Urban Jr., C. K. Argo, and J. V. Weinstock, “Does the failure to acquire helminthic parasites predispose to Crohn's disease?” The FASEB Journal, vol. 14, no. 12, pp. 1848–1855, 2000. View at Scopus
  4. D. E. Elliott, R. W. Summers, and J. V. Weinstock, “Helminths as governors of immune-mediated inflammation,” International Journal for Parasitology, vol. 37, no. 5, pp. 457–464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. R. M. Maizels, A. Balic, N. Gomez-Escobar, M. Nair, M. D. Taylor, and J. E. Allen, “Helminth parasites—masters of regulation,” Immunological Reviews, vol. 201, pp. 89–116, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. G. Nair, K. J. Guild, and D. Artis, “Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy,” The Journal of Immunology, vol. 177, no. 3, pp. 1393–1399, 2006. View at Scopus
  7. M. M. Hunter, A. Wang, C. L. Hirota, and D. M. McKay, “Neutralizing anti-IL-10 antibody blocks the protective effect of tapeworm infection in a murine model of chemically induced colitis,” The Journal of Immunology, vol. 174, no. 11, pp. 7368–7375, 2005. View at Scopus
  8. D. M. McKay, “The therapeutic helminth?” Trends in Parasitology, vol. 25, no. 3, pp. 109–114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. J. van Kruiningen and A. B. West, “Iatrogenic Trichuris suis infection,” Archives of Pathology and Laboratory Medicine, vol. 131, no. 2, p. 180, 2007. View at Scopus
  10. R. W. Summers, D. E. Elliot, J. F. Urban Jr., R. Thompson, and J. V. Weinstock, “Trichuris suis therapy in Crohn's disease,” Gut, vol. 54, no. 1, pp. 87–90, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Mortimer, A. Brown, J. Feary, et al., “Dose-ranging study for trials of therapeutic infection with Necator americanus in humans,” American Journal of Tropical Medicine and Hygiene, vol. 75, no. 5, pp. 914–920, 2006. View at Scopus
  12. R. Persaud, A. Wang, C. Reardon, and D. M. McKay, “Characterization of the immuno-regulatory response to the tapeworm Hymenolepis diminuta in the non-permissive mouse host,” International Journal for Parasitology, vol. 37, no. 3-4, pp. 393–403, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Lamrani, M. Tulliez, L. Chauvelot-Moachon, et al., “Effects of octreotide treatment on early TNF-α production and localization in experimental chronic colitis,” Alimentary Pharmacology and Therapeutics, vol. 13, no. 5, pp. 583–594, 1999. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Stein, J. Ries, and K. E. Barrett, “Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells,” American Journal of Physiology, vol. 274, no. 1, pp. G203–G209, 1998. View at Scopus
  15. A. Sood, V. Midha, N. Sood, and G. Awasthi, “A prospective, open-label trial assessing dexamethasone pulse therapy in moderate to severe ulcerative colitis,” Journal of Clinical Gastroenterology, vol. 35, no. 4, pp. 328–331, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. M. M. Hunter, A. Wang, and D. M. McKay, “Helminth infection enhances disease in a murine TH2 model of colitis,” Gastroenterology, vol. 132, no. 4, pp. 1320–1330, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Wang and D. M. McKay, “Immune modulation by a high molecular weight fraction from the rat tapeworm Hymenolepis diminuta,” Parasitology, vol. 130, no. 5, pp. 575–585, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. B. E. Sands, “Inflammatory bowel disease: past, present, and future,” Journal of Gastroenterology, vol. 42, no. 1, pp. 16–25, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. R. Ehrenstein, J. G. Evans, A. Singh, et al., “Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFα therapy,” Journal of Experimental Medicine, vol. 200, no. 3, pp. 277–285, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Desowitz, “Harmonius parasites,” in New Guinea Tapeworms and Jewish Grandmothers, pp. 179–205, Pickwick, London, UK, 1981.
  21. J. V. Weinstock and D. E. Elliott, “Helminths and the IBD hygiene hypothesis,” Inflammatory Bowel Diseases, vol. 15, no. 1, pp. 128–133, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. M. N. Ince, D. E. Elliott, T. Setiawan, et al., “Role of T cell TGF-β signaling in intestinal cytokine responses and helminthic immune modulation,” European Journal of Immunology, vol. 39, no. 7, pp. 1870–1878, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Daniel, N. A. Sartory, N. Zahn, H. H. Radeke, and J. M. Stein, “Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile,” Journal of Pharmacology and Experimental Therapeutics, vol. 324, no. 1, pp. 23–33, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Cannarile, S. Cuzzocrea, L. Santucci, et al., “Glucocorticoid-induced leucine zipper is protective in Th1-mediated models of colitis,” Gastroenterology, vol. 136, no. 2, pp. 530–541, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. O. Atug, H. Hamzaoglu, V. Tahan, et al., “Hyperbaric oxygen therapy is as effective as dexamethasone in the treatment of TNBS-E-induced experimental colitis,” Digestive Diseases and Sciences, vol. 53, no. 2, pp. 481–485, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. E. van Meeteren, M. A. C. Meijssen, and F. J. Zijlstra, “The effect of dexamethasone treatment on murine colitis,” Scandinavian Journal of Gastroenterology, vol. 35, no. 5, pp. 517–521, 2000. View at Scopus