Volume Density, Distribution, and Ultrastructure of Secretory and Basolateral Membranes and Mitochondria Predict Parietal Cell Secretory (Dys)function
Figure 1
WT parietal cells (left and right). Right panel shows tubulovesicles similar to those boxed in (a). (b) Parietal cells from omeprazole treated mice: WT (left) and NHE2/ (right). Insets show tubulovesicles from areas similar to those boxed in WT and NHE2/ omeprazole-treated mice, respectively. Microvilli were significantly longer and the Vd of mitochondria was reduced in NHE2/ parietal cells compared to WT. Tubulovesicles in NHE2/ parietal cells were mostly vesicular, and often contained electron-dense cores. N: nucleus; arrowheads: mitochondria; arrows: canaliculi, boxes surround TV.
