BioMed Research International

Research Article

Volume Density, Distribution, and Ultrastructure of Secretory and Basolateral Membranes and Mitochondria Predict Parietal Cell Secretory (Dys)function

Table 1

Number of achlorhydric mouse genotypes showing membrane Vd ratios significantly different than WT.
Vd ratioNumber significantMouse Model
TV+CAM+BLM/mitochondria2/6GHKA 𝛼 , NHE2GHKA 𝛼
CAM /TV3/6AE2, GHKA 𝛼 , NHE2, NHE2AE2
Round vesicles/TV2/6GHKA 𝛼 , NHE2GHKA 𝛼
All membranes/mitochondria5/6AE2, GHKA 𝛼 , NHE2, NHE4 NHE2AE2
BLM /mitochondria6/6AE2, GHKA 𝛼 , NHE2, NHE4 NHE2AE2. NHE2GHKA 𝛼
Acid secretion was inhibited either by omeprazole treatment or vagotomy. Values for WT parietal cells with acid secretion inhibited were significantly different than untreated WT for Vd of CAM/TV, round vesicles/TV, and basolateral membrane/mitochondria. NHE2 − / − inhibited parietal cells were not significantly different than NHE2 − / − untreated.