MHC I Stabilizing Potential of Computer-Designed Octapeptides

Figure 1

Structural model of murine MHC I molecule H2-K^b with bound octapeptide SQYYYNSL. (a) Crystal structure model of H-2K^b with bound octapeptide SQYYYNSL (PDB entry 2clv [33]). Top view of the peptide binding groove: red: alpha helices; yellow: beta sheets; blue: octapeptide SQYYYNSL, amino acids of the anchor positions are shown as sticks. (b) Schematic side view of the peptide binding groove with the bound octapeptide SQYYYNSL; Amino acid side chains at the anchor positions are shown as sticks. (c) The octapeptide SQYYYNSL with boxed anchor positions of the canonical motif.

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