MHC I Stabilizing Potential
of Computer-Designed
Octapeptides
Figure 2
Self-organizing map (SOM) projection of MHC I stabilizing peptides. The SOM was trained with 100,603 octapeptides (603 peptides with known binding affinity and 100,000 octamer sequences randomly generated according to the amino acid frequency of M. musculus proteins). Only the distribution of the known stabilizing peptides is shown. The color of a neuron reflects its relative occupancy (white: empty; light blue: slightly occupied; dark blue: most occupied). (a) Distribution of the known 251 stabilizing octapeptides. (b) Distribution of 80 stabilizing octapeptides with amino acid sequences corresponding to the canonical motif in all three anchor positions. (c) Distribution of 152 stabilizing octapeptides with amino acid sequences corresponding to the canonical motif in two residue positions.
