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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 401537, 5 pages
http://dx.doi.org/10.1155/2010/401537
Research Article

Analysis of Adiponectin Gene Polymorphisms in Chinese Population with Systemic Lupus Erythematosus

1Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
2Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Received 11 January 2010; Accepted 15 March 2010

Academic Editor: George C. Tsokos

Copyright © 2010 Wen Liang Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Adiponectin is an adipocyte-derived cytokine with anti-inflammatory, antidiabetic, and antiatherogenic properties. No study has reported on the association between adiponectin (ADIPOQ) gene and SLE. Our aim is to investigate the association between single-nucleotide polymorphisms in ADIPOQ gene and SLE. We examined 179 SLE patients and 237 age- and gender-matched controls from Sichuan province in China. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. Results show that there was no significant difference in the allele frequencies of rs1501299 ( 𝑃 = . 3 1 1 , O R = 1 . 1 7 , 95% CI: 0.86–1.59) and rs2241766 ( 𝑃 = . 9 2 9 , O R = 0 . 9 9 , 95% CI: 0.74–1.33) in ADIPOQ gene between SLE patients and controls. The same results were seen in their genotypes ( 𝑃 < . 0 5 ). The allele frequencies of rs1501299 and rs2241766 polymorphisms of ADIPOQ may not be associated with SLE risk.