ZO proteins interact with transmembrane proteins and with peripheral cytoplasmic proteins at the junctional site. Details are mentioned in the text. Some proteins interacting with ZO proteins are not included in the figure since their association domain is less well described. These include CAR (coxsackievirus and adenovirus receptor), tricellulin, and cingulin. ABR: actin binding region; AF-6: ALL-1 fusion partner at chromosome 6; Apg-2: (ATP and peptide-binding protein in germ cells)-2; Cx: Connexin; Ga12: G protein 12 subunit; GUK: Guanylate kinase-like domain; JAM: Junction adhesion molecule; hScrib: human Scribble; PATJ: Protein associated with tight junctions; P-P-P: Proline-rich region; PDZ: Psd95/discs large/zonula occludens-1 domain; SAF-B: Scaffold attachment factor-B; SH3: Src homology3 domain; U1-U6: Unique variable domains; ZAK: ZO-1 associated kinase; ZONAB: ZO-1 associated nucleic acid binding protein; ZU5: Domain present in ZO-1 and Unc5-like netrin receptors.
