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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 418157, 14 pages
Characterization of Major Surface Protease Homologues of Trypanosoma congolense
1Department of Microbiology and Immunology, University of Saskatchewan, A302 Health Science Building, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
2Department of Veterinary Microbiology, University of Saskatchewan, A302 Health Science Building, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
Received 15 July 2009; Accepted 12 October 2009
Academic Editor: Abhay R. Satoskar
Copyright © 2010 Veronica Marcoux et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. W. Mulligan and W. H. Potts, Eds., The African Trypanosomiases, Wiley-InterScience, New York, NY, USA, 1970.
- M. P. Barrett, R. J. Burchmore, A. Stich, et al., “The trypanosomiases,” The Lancet, vol. 362, pp. 1469–1480, 2003.
- J. D. Barry and R. McCulloch, “Antigenic variation in trypanosomes: enhanced phenotypic variation in a eukaryotic parasite,” Advances in Parasitology, vol. 49, pp. 1–70, 2001.
- G. A. M. Cross, “Cellular and genetic aspects of antigenic variation in trypanosomes,” Annual Review of Immunology, vol. 8, pp. 83–110, 1990.
- R. McCulloch, “Antigenic variation in African trypanosomes: monitoring progress,” Trends in Parasitology, vol. 20, no. 3, pp. 117–121, 2004.
- E. Pays, “Regulation of antigen gene expression in Trypanosoma brucei,” Trends in Parasitology, vol. 21, no. 11, pp. 517–520, 2005.
- D. J. LaCount, A. E. Gruszynski, P. M. Grandgenett, J. D. Bangs, and J. E. Donelson, “Expression and function of the Trypanosoma brucei major surface protease (GP63) genes,” Journal of Biological Chemistry, vol. 278, no. 27, pp. 24658–24664, 2003.
- J. D. Bangs, D. A. Ransom, M. Nimick, G. Christie, and N. M. Hooper, “In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors,” Molecular and Biochemical Parasitology, vol. 114, no. 1, pp. 111–117, 2001.
- C. Yao, J. E. Donelson, and M. E. Wilson, “The major surface protease (MSP or GP63) of Leishmania sp. Biosynthesis, regulation of expression, and function,” Molecular and Biochemical Parasitology, vol. 132, no. 1, pp. 1–16, 2003.
- H. Tabel, “Activation of the alternative pathway of bovine complement by Trypanosoma congolense,” Parasite Immunology, vol. 4, no. 5, pp. 329–335, 1982.
- G. Wei, L. Qualtiere, and H. Tabel, “Trypanosoma congolense: complement independent immobilization by a monoclonal antibody,” Experimental Parasitology, vol. 70, no. 4, pp. 483–485, 1990.
- M. A. Larkin, G. Blackshields, N. P. Brown, et al., “Clustal W and clustal X version 2.0,” Bioinformatics, vol. 23, no. 21, pp. 2947–2948, 2007.
- P. A. Bates, L. A. Kelley, R. M. MacCallum, and M. J. E. Sternberg, “Enhancement of protein modeling by human intervention in applying the automatic programs 3D-JIGSAW and 3D-PSSM,” Proteins, vol. 45, supplement 5s, pp. 39–46, 2001.
- W. L. DeLano, The PyMOL Molecular Graphics System, DeLano Scientific, Palo Alto, Calif, USA, 2008.
- A. Pierleoni, P. L. Martelli, and R. Casadio, “PredGPI: a GPI-anchor predictor,” BMC Bioinformatics, vol. 9, article 392, 2008.
- J. D. Bendtsen, H. Nielsen, G. von Heijne, and S. Brunak, “Improved prediction of signal peptides: SignalP 3.0,” Journal of Molecular Biology, vol. 340, no. 4, pp. 783–795, 2004.
- S. M. Lanham and D. G. Godfrey, “Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose,” Experimental Parasitology, vol. 28, no. 3, pp. 521–534, 1970.
- W. J. Herbert and W. H. R. Lumsden, “Trypanosoma brucei: a rapid “matching” method for estimating the host's parasitemia,” Experimental Parasitology, vol. 40, no. 3, pp. 427–431, 1976.
- P. M. Grandgenett, K. Otsu, H. R. Wilson, M. E. Wilson, and J. E. Donelson, “A function for a specific zinc metalloprotease of African trypanosomes,” PLoS Pathogens, vol. 3, no. 10, pp. 1432–1445, 2007.
- E. Schlagenhauf, R. Etges, and P. Metcalf, “The crystal structure of the Leishmania major surface proteinase leishmanolysin (GP63),” Structure, vol. 6, no. 8, pp. 1035–1046, 1998.
- C. A. Buscaglia, V. A. Campo, A. C. Frasch, and J. M. Di Noia, “Trypanosoma cruzi surface mucins: host-dependent coat diversity,” Nature Reviews Microbiology, vol. 4, no. 3, pp. 229–236, 2006.
- B. R. Voth, B. L. Kelly, P. B. Joshi, A. C. Ivens, and W. R. McMaster, “Differentially expressed Leishmania major GP63 genes encode cell surface leishmanolysin with distinct signals for glycosylphosphatidylinositol attachment,” Molecular and Biochemical Parasitology, vol. 93, no. 1, pp. 31–41, 1998.
- M. Halle, M. A. Gomez, M. Stuible, et al., “The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38mitogen-activated protein kinase inactivation,” Journal of Biological Chemistry, vol. 284, no. 11, pp. 6893–6908, 2009.
- I. L. Mauricio, M. W. Gaunt, J. R. Stothard, and M. A. Miles, “Glycoprotein 63 (GP63) genes show gene conversion and reveal the evolution of Old World Leishmania,” International Journal for Parasitology, vol. 37, no. 5, pp. 565–576, 2007.
- A. Brittingham, C. J. Morrison, W. R. McMaster, B. S. McGwire, K.-P. Chang, and D. M. Mosser, “Role of the Leishmania surface protease GP63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis,” The Journal of Immunology, vol. 155, no. 6, pp. 3102–3111, 1995.
- F. R. Rurangirwa, H. Tabel, G. Losos, and I. R. Tizard, “Hemolytic complement and serum C3 levels in zebu cattle infected with Trypanosoma congolense and Trypanosoma vivax and the effect of trypanocidal treatment,” Infection and Immunity, vol. 27, no. 3, pp. 832–836, 1980.
- M. N. Malu and H. Tabel, “The alternative pathway of complement in sheep during the course of infection with Trypanosoma congolense and after Berenil treatment,” Parasite Immunology, vol. 8, no. 3, pp. 217–229, 1986.
- E. B. Otesile, M. Lee, and H. Tabel, “Plasma levels of proteins of the alternative complement pathway in inbred mice that differ in resistance to Trypanosoma congolense infections,” Journal of Parasitology, vol. 77, no. 6, pp. 958–964, 1991.
- W. Pan, O. Ogunremi, G. Wei, M. Shi, and H. Tabel, “CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor and nitric oxide,” Microbes and Infection, vol. 8, no. 5, pp. 1209–1218, 2006.
- H. Tabel, R. S. Kaushik, and J. E. Uzonna, “Susceptibility and resistance to Trypanosoma congolense infections,” Microbes and Infection, vol. 2, no. 13, pp. 1619–1629, 2000.
- H. Tabel, G. Wei, and M. Shi, “T cells and immunopathogenesis of experimental African trypanosomiasis,” Immunological Reviews, vol. 225, no. 1, pp. 128–139, 2008.
- G. Wei and H. Tabel, “Regulatory T cells prevent control of experimental African trypanosomiasis,” The Journal of Immunology, vol. 180, no. 4, pp. 2514–2521, 2008.
- D. N. Ermolenko, A. V. Zherdev, B. B. Dzantiev, and V. O. Popov, “Antiperoxidase antibodies enhance refolding of horseradish peroxidase,” Biochemical and Biophysical Research Communications, vol. 291, no. 4, pp. 959–965, 2002.
- M. H. Macdonald, C. J. Morrison, and W. R. McMaster, “Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63,” Biochimica et Biophysica Acta, vol. 1253, no. 2, pp. 199–207, 1995.