Table 1: Major surface protease homologues.

NumberSpeciesIdentifier*Probability of a signal peptideProbability of a GPI anchor

1T. cruziXM_808234High (29-30)moderate
2T. cruziXM_806897Not probablenot probable
3T. vivax1037d01.p1kHigh (36-37)not probable
4T. congolenseTcoMSP-DHigh (23-24)not probable
5T.b. gambiense11_v2.orf-3High (23-24not probable
6T. brucei TREU927XM_823726High (23-24)not probable
7L. brazilliensisXM_001562766High (30-31)not probable
8L. guyanensisLEIGP63XHigh (41-42)High
9L. mexicanaX64394High (41-42)not probable
10L. donovaniAJ495007High (41-42)not probable
11L. majorXM_001681325High (41-42)High
12L. majorXM_001681324High (41-42)High
13L. majorXM_001684283High (24-25)High
14L. infantumXM_001470056High (24-25)High
15T. cruziXM_802134High (28-29)not probable
16T. cruziXM_807916High (30-31)not probable
17T. cruziXM_801120High (29-30)not probable
18T. cruziXM_799438High (29-30)not probable
19T. vivax942f04.q1kHigh (30-31)low
20T. vivax1924b07.q1kHigh (36-37)High
21T. vivax1240d01.p1kHigh (36-37)High
22T. congolenseTcoMSP-CHigh (30-31)not probable
23T.b. gambiense10_v2High (24-25)not probable
24T.b TREU927TbMSP-C=XM_817402High (24-25)not probable
25T. cruziXM_799266High (27-28)High
26T. cruziXM_802023High (59-60)moderate
27T. cruziXM_798784High (59-60)moderate
28T. cruziXM_815532High (22-23)High
29T. cruziXM_815930Poor (24-25)moderate
30T. cruziXM_812094High (20-21)High
31T. cruziXM_798806High (22-23)High
32T. congolenseTcoMSP-B1High (21-22)High
33T. congolenseTcoMSP-B2High (21-22)High
34T. brucei TREU927XM_841902High (58-59)High
35T.b. gambiense08_v2High (58-59)High
36T. brucei TREU927XM_841905High (64-65)moderate
37T.brucei TREU927TbMSP-B=XM_841904High (64-65)moderate
38T. vivax1393e12.p1kHigh (20-21)not probable
39T. vivax797h07.q1kHigh (22-23)not probable
40T. vivax899g05.p1kHigh (19-20)not probable
41T. congolenseTcoMSP-AHigh (27-28)moderate
42T. brucei TREU927XM_823758High (26-27)High
43T.b. gambiense1167d01.p1kHigh (26-27)High
44T.b. rhodesienseMSP-A2High (26-27)High
45T. brucei TREU927XM_823757High (26-27)High
46T. b. gambiense11_v2-orf2High (26-27)High
47T.b. gambiense2537b02.p1kHigh (26-27)High
48T. brucei TREU927XM_823755High (26-27)High
49T.b. rhodesienseMSP-A1High (26-27)High
50T.b. rhodesienseTbMSP-A=U86345High (26-27)High
51T. vivax1124g05.p1kHigh (28-29)low
52T. vivax1764g03.p1kHigh (23-24)moderate
53T. congolenseTcoMSP-Enot probablenot probable
54T. brucei TREU927XM_823843not probablenot probable
55T.b. gambiense11_v2-orf1not probablelow

*See supplementary data for full protein sequences.