Identification of microRNAs Involved in the Host Response to Enterovirus 71 Infection by a Deep Sequencing Approach

Table 5

Reverse regulatory association of down-regulated miRNAs and their predicted mRNA targets.

Down-regulated miRNA	Target genes	Functions	Reference
hsa-mir-27	Cytochrome P450,superfamily I polypeptide 1	Mitochondrial function	[20]
hsa-mir-26a,hsa-mir-27	BCL2-antagonist/killer 1	Apoptosis	[20]
hsa-mir-26a	Programmed cell death 10		[20]
hsa-mir-582	Amyloid beta (A4) precursor protein		[20]
hsa-mir-19	BCL2-associated athanogene 5		[20]
hsa-mir-1180,hsa-mir-19,hsa-mir-582,hsa-mir-26a,hsa-mir-30a,hsa-let-7e,hsa-mir-545	calcium channel, voltage-dependent, L type, alpha 1C subunit	Membrane transporters	[20]
hsa-mir-433,hsa-let-7e	Cathepsin C	Protein degradation	[20]
hsa-mir-26a,hsa-mir-545	Muscle RAS oncogene homolog	Oncogene	[20]
hsa-mir-19	RAB5B, member RAS oncogene family		[20]
hsa-mir-19	neurotrophic tyrosine kinase, receptor, type 2	Kinases and phosphatases	[20]
hsa-mir-19	Fas-activated serine/threonine kinase		[20]
hsa-mir-582,hsa-let-7e	adaptor-related protein complex 1, sigma 1 subunit	trafficking and targeting proteins	[21]
hsa-mir-27	actin, alpha 2, smooth muscle, aorta	cytoskeleton/motility	[21]