Review Article

Pathogenesis of Insulin Resistance in Skeletal Muscle

Figure 3

Insulin-stimulated glucose disposal (40 mU/m2 min euglycemic insulin clamp) in lean healthy control (CON) subjects, lean drug naïve type 2 diabetic subjects (T2DM), lean normal-glucose-tolerant (NGT) hypertensive subjects (HTN), NGT hypertriglyceridemic subjects, and nondiabetic subjects with coronary artery disease (CAD). The open portion of the bar represents nonoxidative glucose disposal (glycogen synthesis) and the solid portion represents glucose oxidation. See DeFronzo and Ferrannini [80], DeFronzo [81].
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