Pathogenesis of Insulin Resistance in Skeletal Muscle

Figure 5

In insulin resistant individuals insulin signaling is impaired at the level of IRS-1 leading to decreased glucose transport/phosphorylation/metabolism and impaired nitric oxide synthase activation/endothelial function. Increased intramycellar fat and fatty acid meyabolite content and mitochondrial dysfunction also exist in skeletal muscle in insulin resistant individuals (see text for a detailed discussion).