Review Article

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases

Figure 5

The evolution of genetic diseases under 𝐽 O o M m , maternal dominant by zygotic dominant epistasis. (a) Simulations which track the evolution of maternally expressed alleles and zygotically expressed alleles under different levels of epistasis without direct purifying selection. (b) Simulations which track the evolution of zygotically expressed alleles under different levels of epistasis with direct purifying selection on the zygotically expressed allele. (c) Simulations which track the evolution of maternally expressed alleles under different levels of epistasis with direct purifying selection on the maternally expressed allele.
478732.fig.005a
(a)
478732.fig.005b
(b)
478732.fig.005c
(c)