BioMed Research International

Review Article

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases

Table 1

The genotypic values of two zygotically expressed interacting genes. Each gene has two alleles with genetic effects decomposed into eight orthogonal components: additive ( 𝛼 and 𝛽 , dominance ( 𝐷 A and 𝐷 B ), additive by additive ( 𝐼 A B ) , additive by dominance ( 𝐾 A B b ) , dominance by additive ( 𝐾 A a B ) , and dominance by dominance ( 𝐽 A a B b ) .
GenotypesBBBbbb
AA 1 + 𝛼 + 𝛽 + 𝐼 A B 1 + 𝛼 + 𝐷 B + 𝐾 A B b 1 + 𝛼 − 𝛽 − 𝐼 A B
Aa 1 + 𝛽 + 𝐷 A + 𝐾 A a B 1 + 𝐷 A + 𝐷 B + 𝐽 A a B b 1 − 𝛽 + 𝐷 A − 𝐾 A a B
aa 1 − 𝛼 + 𝛽 − 𝐼 A B 1 − 𝛼 + 𝐷 B − 𝐾 A B b 1 − 𝛼 − 𝛽 + 𝐼 A B