BioMed Research International

Review Article

Maternal-Zygotic Epistasis and the Evolution of Genetic Diseases

Table 2

The genotypic fitness values for a pair of maternally and zygotically expressed interacting genes expressed as deviations to be added to 1. Each gene has two alleles with genetic effects decomposed into eight orthogonal components: zygotic additive ( 𝜙 ) and zygotic dominant ( 𝐷 O ) , maternal additive ( 𝜅 ) and maternal dominant ( 𝐷 M ) , zygotic additive by maternal additive ( 𝐼 O M ) , zygotic dominant by maternal additive ( 𝐾 O o M ) , zygotic additive by maternal dominant ( 𝐾 O M m ) , and zygotic dominant by maternal dominant ( 𝐽 O o M m ) .
Offspring Genotypes
Maternal GenotypesOOOooo
MM1 + 𝜙 + 𝜅 + 𝐼 O M 1 + 𝜅 + 𝐷 O + 𝐾 O o M 1 − 𝜙 + 𝜅 − 𝐼 O M
Mm 1 + 𝜙 + 𝐷 M + 𝐾 O M m 1 + 𝐷 O + 𝐷 M + 𝐽 O o M m 1 − 𝜙 + 𝐷 M − 𝐾 O M m
mm 1 + 𝜙 − 𝜅 − 𝐼 O M 1 − 𝜅 + 𝐷 O − 𝐾 O o M 1 − 𝜙 − 𝜅 + 𝐼 O M