Testosterone Depletion by Castration May Protect Mice from Heat-Induced Multiple Organ Damage and Lethality

Table 1

Plasma levels of testosterone for different groups of mice.

Treatment groups	Plasma testosterone (pg/mL)
(1) Normothermic controls (NCs)	403±91
(2) Sham-operated heatstroke (SOH) mice	525±115
(3) Castrated, vehicle-treated heatstroke (CVH) mice	4±2^∗
(4) Castrated, testosterone-treated heatstroke (CTH) mice	260±24^∗,∗∗

* 𝑃<.01 in comparison with group 1 or group 2;
** 𝑃<.05 in comparison with group 3. The blood sampling was obtained for testosterone assay immediately before the start of thermal experiments (or 14 days after vehicle or testosterone treatment). Data are means ± SEM of 7 mice per group.