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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 506762, 8 pages
Research Article

The Immunoexpression of FSH-R in the Ductuli Efferentes and the Epididymis of Men and Rat: Effect of FSH on the Morphology and Steroidogenic Activity of Rat Epididymal Epithelial Cells In Vitro

1Department of Histology and Embryology, Pomeranian Medical University, 72 Powstańców Wlkp. Street, 70-111 Szczecin, Poland
2Department of Urology, Pomeranian Medical University, 72 Powstańców Wlkp. Street, 70-111 Szczecin, Poland
3Department of Biochemistry and Human Nutrition, Pomeranian Medical University, 48 Żołnierska Street, 71-210 Szczecin, Poland

Received 20 July 2009; Revised 20 November 2009; Accepted 5 March 2010

Academic Editor: Pavel Hozak

Copyright © 2010 Małgorzata Świder-Al-Amawi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Sertoli cells were regarded as the only target for FSH in male reproductive system. The expression of FSH receptor (FSH-R) was detected also in epithelial cells of the caput epididymis of rat and monkey. We showed in the immunohistochemistry study the expression of FSH-R in rat and human ductuli efferentes and the caput, corpus, and cauda epididymis, moreover, by Western blot analysis in the caput and cauda epididymis of rat. Additionally, we presented that the morphology of rat epididymal epithelial cells in vitro was affected by FSH, and FSH stimulation resulted in the increase of 17 š¯›½ -estradiol synthesis by rat caput epididymal cells in dose-depended manner. In conclusion, the identification of FSH receptors in human and rat epididymides supports our results that the epididymis is a target organ not only for LH but additionally for FSH. On the basis of the results we showed for the first time that morphology of epididymal epithelial cells and epididymal steroidogenesis can be regulated by FSH.