The change in gene expression in SLE or cytokine-treated samples was matched by H4ac changes in the same samples. (a) Upregulated genes seen in SLE or after cytokine treatment were examined for H4ac content. The top 200 genes with the highest expression change caused by SLE or cytokines, as was identified by previous analysis were included. (b) Down-regulated genes seen in SLE or after cytokine treatment were examined for H4ac content. The 200 genes most down-regulated were examined. The black contour indicates the average H4ac in control samples and the colored regions correspond to the amount of H4ac increase (red) or decrease (green) in SLE or cytokine-treated samples.
