About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 513853, 7 pages
http://dx.doi.org/10.1155/2010/513853
Research Article

Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats

1Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
2Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
3Graduate Institute of Basic Medical Science, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
4Department of Pharmacology, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
5Department of Medical Research, Chi-Mei Medical Center, Yong Kang City 73101, Taiwan

Received 24 February 2010; Accepted 22 April 2010

Academic Editor: Nathan Ames Ellis

Copyright © 2010 Meng-Fu Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Sistiana Aiello, and Marina Noris, “Klotho in acute kidney injury: biomarker, therapy, or a bit of both?,” Kidney International, vol. 78, no. 12, pp. 1208–1210, 2010. View at Publisher · View at Google Scholar
  • Yanhua Zhao, Srijita Banerjee, Nilay Dey, Wanda S. LeJeune, Partha S. Sarkar, Reynolds Brobey, Kevin P. Rosenblatt, Ronald G. Tilton, and Sanjeev Choudhary, “Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)(536) Phosphorylation,” Diabetes, vol. 60, no. 7, pp. 1907–1916, 2011. View at Publisher · View at Google Scholar
  • Rong Tang, Qiaoling Zhou, Zhichun Liu, Zhou Xiao, and Veeraragoo Pouranan, “Effects of fosinopril and losartan on renal Klotho expression and oxidative stress in spontaneously hypertensive rats,” Journal of Central South University (Medical Sciences), vol. 36, no. 1, pp. 27–33, 2011. View at Publisher · View at Google Scholar
  • Rong Tang, Qiao-ling Zhou, Xiang Ao, Wei-sheng Peng, Pouranan Veeraragoo, and Tian-feng Tang, “Fosinopril and Losartan Regulate Klotho Gene and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Expression in Kidneys of Spontaneously Hypertensive Rats,” Kidney & Blood Pressure Research, vol. 34, no. 5, pp. 350–357, 2011. View at Publisher · View at Google Scholar
  • Sridevi Devaraj, Basir Syed, Alexander Chien, and Ishwarlal Jialal, “Validation of an Immunoassay for Soluble Klotho Protein Decreased Levels in Diabetes and Increased Levels in Chronic Kidney Disease,” American Journal Of Clinical Pathology, vol. 137, no. 3, pp. 479–485, 2012. View at Publisher · View at Google Scholar
  • M. C. Izquierdo, M. V. Perez-Gomez, M. D. Sanchez-Nino, A. B. Sanz, O. Ruiz-Andres, J. Poveda, J. A. Moreno, J. Egido, and A. Ortiz, “Klotho, phosphate and inflammation/ageing in chronic kidney disease,” Nephrology Dialysis Transplantation, vol. 27, no. suppl4, pp. iv6–iv10, 2012. View at Publisher · View at Google Scholar
  • Ina Maria Kacso, Cosmina Ioana Bondor, and Gabriel Kacso, “Soluble serum Klotho in diabetic nephropathy: Relationship to VEGF-A,” Clinical Biochemistry, vol. 45, no. 16-17, pp. 1415–1420, 2012. View at Publisher · View at Google Scholar
  • Iulia-Daniela Vladu, Daniela Cana, Cristina Vaduva, Corina Grauntanu, Sorin Zaharie, Raluca Dina, Ciprian Dina, Roxana Mustafa, and Eugen Mota, “Chronic Kidney Disease-Mineral Bone Disorder in Diabetes Mellitus Patients,” Romanian Journal of Diabetes Nutrition and Metabolic Diseases, vol. 19, no. 1, 2012. View at Publisher · View at Google Scholar
  • S.M. Nourazarian, G. Irajian, M. Najafi, M. Nourbakhsh, J. Maleki, and M. Shabani, “The effect of Lactobacillus reuteri on bone morphogenetic protein-7 and beta transforming growth factor gene expressions in streptozotocin-induced diabetic rat's kidneys,” Pakistan Journal of Biological Sciences, vol. 15, no. 8, pp. 374–379, 2012. View at Publisher · View at Google Scholar
  • Ming Chang Hu, Makoto Kuro-O, and Orson W. Moe, “Secreted Klotho and chronic kidney disease,” Advances in Experimental Medicine and Biology, vol. 728, pp. 126–157, 2012. View at Publisher · View at Google Scholar
  • Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Shinichi Egawa, and Michiaki Unno, “Animal Models of Diabetes Mellitus for Islet Transplantation,” Experimental Diabetes Research, vol. 2012, pp. 1–11, 2012. View at Publisher · View at Google Scholar
  • Min-Tser Liao, Chih-Chien Sung, Kuo-Chin Hung, Chia-Chao Wu, Lan Lo, and Kuo-Cheng Lu, “Insulin Resistance in Patients with Chronic Kidney Disease,” Journal of Biomedicine and Biotechnology, vol. 2012, pp. 1–12, 2012. View at Publisher · View at Google Scholar
  • Gang Jee Ko, Eun Ah Lee, Un Sil Jeon, Heui Jung Pyo, Ho Jun Chin, Dong Wan Chae, Suhnggwon Kim, and Young Joo Kwon, “The association of Klotho polymorphism with disease progression and mortality in IgA nephropathy,” Kidney and Blood Pressure Research, vol. 36, no. 1, pp. 191–199, 2012. View at Publisher · View at Google Scholar
  • Ming Chang Hu, Makoto Kuro-o, and Orson W. Moe, “Renal and Extrarenal Actions of Klotho,” Seminars in Nephrology, vol. 33, no. 2, pp. 118–129, 2013. View at Publisher · View at Google Scholar
  • Amit Agrawal, B.V. Subrahmanyan, and G. Malleswara Rao, “Blast injury causing extensive brain injury and elevated skull fracture,” The Indian Journal of Neurotrauma, 2013. View at Publisher · View at Google Scholar
  • Martina Feger, Abul Fajol, Aleksandra Lebedeva, Adrian Meissner, Diana Michael, Jakob Voelkl, Ioana Alesutan, Erwin Schleicher, Christoph Reichetzeder, Berthold Hocher, and Syed M. Qadri, “Effect of Carbon Monoxide Donor CORM-2 on Vitamin D-3 Metabolism,” Kidney & Blood Pressure Research, vol. 37, no. 4-5, pp. 496–505, 2013. View at Publisher · View at Google Scholar
  • My Qi Min-you, Gy Xie Gao-yu, K Chen Kai, Yh Su Yan-hui, Sq Yu Su-qing, and Hr Liu Hao-ran, “Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats,” Chinese Journal of Integrative Medicine, vol. 20, no. 6, pp. 456–461, 2014. View at Publisher · View at Google Scholar
  • K-C Huang, Y-G Cherng, L-J Chen, C-T Hsu, and J-T Cheng, “Rosiglitazone is Effective to Improve Renal Damage in Type-1-like Diabetic Rats,” Hormone and Metabolic Research, vol. 46, no. 4, pp. 240–244, 2014. View at Publisher · View at Google Scholar
  • S. L. Barker, J. Pastor, D. Carranza, H. Quinones, C. Griffith, R. Goetz, M. Mohammadi, J. Ye, J. Zhang, M. C. Hu, M. Kuro-o, O. W. Moe, and S. S. Sidhu, “The demonstration of  Klotho deficiency in human chronic kidney disease with a novel synthetic antibody,” Nephrology Dialysis Transplantation, 2014. View at Publisher · View at Google Scholar
  • Priya Ravikumar, Jianfeng Ye, Jianning Zhang, Sydney N. Pinch, Ming Chang Hu, Makoto Kuro-o, Connie C. W. Hsia, and Orson W. Moe, “alpha-Klotho protects against oxidative damage in pulmonary epithelia,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 307, no. 7, pp. L566–L575, 2014. View at Publisher · View at Google Scholar
  • M. -F. Cheng, L. -J. Chen, M. -C. Wang, C. -T. Hsu, and J. -T. Cheng, “Decrease of FGF Receptor (FGFR) and Interstitial Fibrosis in the Kidney of Streptozotocin-induced Diabetic Rats,” Hormone and Metabolic Research, vol. 46, no. 01, pp. 1–7, 2014. View at Publisher · View at Google Scholar
  • Mohammad Parvizi, Mohsen Parviz, Seyed Tavangar, Nepton Soltani, Mehri Kadkhodaee, Behjat Seifi, Yaser Azizi, and Mansoor Keshavarz, “Protective effect of magnesium on renal function in STZ-induced diabetic rats,” Journal of Diabetes & Metabolic Disorders, vol. 13, no. 1, pp. 84, 2014. View at Publisher · View at Google Scholar