- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 513853, 7 pages
Decrease of Klotho in the Kidney of Streptozotocin-Induced Diabetic Rats
1Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
2Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
3Graduate Institute of Basic Medical Science, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
4Department of Pharmacology, College of Medicine, National Cheng Kung University Hospital, Tainan City 70101, Taiwan
5Department of Medical Research, Chi-Mei Medical Center, Yong Kang City 73101, Taiwan
Received 24 February 2010; Accepted 22 April 2010
Academic Editor: Nathan Ames Ellis
Copyright © 2010 Meng-Fu Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Kuro-o, Y. Matsumura, and Y. Matsumura, “Mutation of the mouse klotho gene leads to a syndrome resembling ageing,” Nature, vol. 390, no. 6655, pp. 45–51, 1997.
- Y. Haruna, N. Kashihara, and N. Kashihara, “Amelioration of progressive renal injury by genetic manipulation of Klotho gene,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 7, pp. 2331–2336, 2007.
- F. P. Schena and L. Gesualdo, “Pathogenetic mechanisms of diabetic nephropathy,” Journal of the American Society of Nephrology, vol. 16, supplement 1, pp. S30–S33, 2005.
- Y. Ohkubo, H. Kishikawa, and H. Kishikawa, “Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study,” Diabetes Research and Clinical Practice, vol. 28, no. 2, pp. 103–117, 1995.
- S. V. Shah, R. Baliga, M. Rajapurkar, and V. A. Fonseca, “Oxidants in chronic kidney disease,” Journal of the American Society of Nephrology, vol. 18, no. 1, pp. 16–28, 2007.
- Y. Ohshiro and N. Takasu, “Molecular mechanism of diabetic nephropathy,” Nippon Rinsho, vol. 64, no. 5, pp. 997–1003, 2006.
- H. Ha and H. B. Lee, “Reactive oxygen species amplify glucose signalling in renal cells cultured under high glucose and in diabetic kidney,” Nephrology, vol. 10, supplement 2, pp. S7–S10, 2005.
- J.-T. Cheng, C.-C. Huang, I.-M. Liu, T.-F. Tzeng, and J. C. Chih, “Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats,” Diabetes, vol. 55, no. 3, pp. 819–825, 2006.
- H. Zhang, Y. Li, and Y. Li, “Klotho is a target gene of PPAR-γ,” Kidney International, vol. 74, no. 6, pp. 732–739, 2008.
- C.-J. Huang, I.-M. Liu, and J.-T. Cheng, “Increase of peroxisome proliferator-activated receptor δ gene expression in the lungs of streptozotocin-induced diabetic rats,” Pulmonary Pharmacology and Therapeutics, vol. 20, no. 1, pp. 69–74, 2007.
- T.-J. Hsieh, S.-L. Zhang, J. G. Filep, S.-S. Tang, J. R. Ingelfinger, and J. S. D. Chan, “High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells,” Endocrinology, vol. 143, no. 8, pp. 2975–2985, 2002.
- M. C. Iglesias-De La Cruz, P. Ruiz-Torres, and P. Ruiz-Torres, “Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells,” Kidney International, vol. 59, no. 1, pp. 87–95, 2001.
- S. M. Mauer, M. W. Steffes, and D. M. Brown, “The kidney in diabetes,” American Journal of Medicine, vol. 70, no. 3, pp. 603–612, 1981.
- M. Hawkins, M. Hu, and M. Hu, “Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity,” The Journal of Biological Chemistry, vol. 274, no. 44, pp. 31312–31319, 1999.
- M. Yamamoto, J. D. Clark, and J. D. Clark, “Regulation of oxidative stress by the anti-aging hormone klotho,” The Journal of Biological Chemistry, vol. 280, no. 45, pp. 38029–38034, 2005.
- M. Ikushima, H. Rakugi, and H. Rakugi, “Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells,” Biochemical and Biophysical Research Communications, vol. 339, no. 3, pp. 827–832, 2006.
- M. Mitobe, T. Yoshida, H. Sugiura, S. Shirota, K. Tsuchiya, and H. Nihei, “Oxidative stress decreases klotho expression in a mouse kidney cell line,” Nephron—Experimental Nephrology, vol. 101, no. 2, pp. e67–e74, 2005.
- H. Sugiura, T. Yoshida, and T. Yoshida, “Klotho reduces apoptosis in experimental ischaemic acute renal failure,” Nephrology Dialysis Transplantation, vol. 20, no. 12, pp. 2636–2645, 2005.