Table 2: Changes in serum glucose, BUN, and creatinine levels in normal rats or streptozotocin-induced diabetic rats (STZ-DN) receiving repeated i.p. injection with vehicle or tiron (300 mg/kg) three times a day for 7 days.

Normal rats-vehicleSTZ-DN-vehicleSTZ-DN-tiron
BeforeAfterBeforeAfterBeforeAfter

Glucose (mg/dL) 1 1 6 . 3 ± 5 . 2 1 2 2 . 9 ± 5 . 3 4 7 8 . 2 ± 1 3 . 8 a 4 8 3 . 7 ± 1 4 . 5 a 4 8 1 . 8 ± 1 3 . 7 a 4 7 3 . 2 ± 1 2 . 3 a
BUN (mg/dL) 1 8 . 2 ± 0 . 8 1 6 . 3 ± 0 . 8 2 9 . 8 ± 0 . 7 a 3 1 . 9 ± 1 . 2 a 3 1 . 4 ± 0 . 4 a 2 2 . 3 ± 0 . 5
Creatinine ( 𝜇 g/dL) 6 1 2 . 7 ± 9 . 8 6 2 1 . 4 ± 4 . 6 7 2 3 . 6 ± 2 1 . 8 a 7 5 3 . 7 ± 1 1 . 4 a b 7 4 4 . 6 ± 1 2 . 3 a 6 1 4 . 8 ± 2 6 . 8 b

Values (mean ± SE) were obtained from each group of six animals. The vehicle used to dissolve the testing drugs was given at the same volume. a 𝑃 < . 0 5 compared to the values of control, b 𝑃 < . 0 5 compared to the values of before vehicle or tiron treatment.