- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 534501, 7 pages
Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice
1Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
2Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
3Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy
4Division of Infectious Diseases, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, P.O. Box 1090, New York, NY 10029, USA
Received 14 December 2009; Revised 27 February 2010; Accepted 9 March 2010
Academic Editor: Kim Klonowski
Copyright © 2010 Donatella R. M. Negri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. J. McMichael, “Principles of immunology,” in Oxford Textbook of Medicine, D. A. Warrell, T. M. Cox, J. D. Firth, and E. J. Benz, Eds., pp. 131–144, Oxford University Press, Oxford, UK, 4th edition, 2003.
- X. Jin, D. E. Bauer, S. E. Tuttleton, et al., “Dramatic rise in plasma viremia after CD T cell depletion in simian immunodeficiency virus-infected macaques,” The Journal of Experimental Medicine, vol. 189, no. 6, pp. 991–998, 1999.
- J. E. Schmitz, M. J. Kuroda, S. Santra, et al., “Control of viremia in simian immunodeficiency virus infection by CD lymphocytes,” Science, vol. 283, no. 5403, pp. 857–860, 1999.
- B. T. Korber, N. L. Letvin, and B. F. Haynes, “T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand faces,” The Journal of Virology, vol. 83, no. 17, pp. 8300–8314, 2009.
- R. A. Koup, M. Roederer, L. Lamoreaux, et al., “Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses,” PLoS ONE, vol. 5, no. 2, article e9015, 2010.
- Y. He and L. D. Falo Jr., “Lentivirus as a potent and mechanistically distinct vector for genetic immunization,” Current Opinion in Molecular Therapeutics, vol. 9, no. 5, pp. 439–446, 2007.
- N. Chinnasamy, D. Chinnasamy, J. F. Toso, et al., “Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors,” Human Gene Therapy, vol. 11, no. 13, pp. 1901–1909, 2000.
- J. Dyall, J.-B. Latouche, S. Schnell, and M. Sadelain, “Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes,” Blood, vol. 97, no. 1, pp. 114–121, 2001.
- M. C. Iglesias, K. Mollier, A.-S. Beignon, et al., “Lentiviral vectors encoding HIV-1 polyepitopes induce broad CTL responses in vivo,” Molecular Therapy, vol. 15, no. 6, pp. 1203–1210, 2007.
- V. Buffa, D. R. M. Negri, P. Leone, et al., “A single administration of lentiviral vectors expressing either full-length human immunodeficiency virus 1 (HIV-1)HXB2 Rev/ Env or codon-optimized HIV-1JR-FL gp 120 generates durable immune responses in mice,” The Journal of General Virology, vol. 87, no. 6, pp. 1625–1634, 2006.
- V. Buffa, D. R. M. Negri, P. Leone, et al., “Evaluation of a self-inactivating lentiviral vector expressing simian immunodeficiency virus gag for induction of specific immune responses in vitro and in vivo,” Viral Immunology, vol. 19, no. 4, pp. 690–701, 2006.
- A.-S. Beignon, K. Mollier, C. Liard, et al., “A lentiviral vector-based prime/boost vaccination against AIDS: a pilot study shows protection against Simian immunodeficiency virus SIVmac251 challenge in macaques,” The Journal of Virology, vol. 83, no. 21, pp. 10963–10974, 2009.
- J. Vargas Jr., G. L. Gusella, V. Najfeld, M. E. Klotman, and A. Cara, “Novel integrase-defective lentiviral episomal vectors for gene transfer,” Human Gene Therapy, vol. 15, no. 4, pp. 361–372, 2004.
- A. Cara and M. E. Klotman, “Retroviral E-DNA: persistence and gene expression in nondividing immune cells,” Journal of Leukocyte Biology, vol. 80, no. 5, pp. 1013–1017, 2006.
- Y. Zheng, I. Ourmanov, and V. M. Hirsch, “Persistent transcription of a nonintegrating mutant of simian immunodeficiency virus in rhesus macrophages,” Virology, vol. 372, no. 2, pp. 291–299, 2008.
- D. R. M. Negri, Z. Michelini, S. Baroncelli, et al., “Successful immunization with a single injection of non-integrating lentiviral vector,” Molecular Therapy, vol. 15, no. 9, pp. 1716–1723, 2007.
- F. Coutant, M.-P. Frenkiel, P. Despres, and P. Charneau, “Protective antiviral immunity conferred by a nonintegrative lentiviral vector-based vaccine,” PLoS ONE, vol. 3, no. 12, article e3973, 2008.
- K. Karwacz, S. Mukherjee, L. Apolonia, et al., “Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy,” The Journal of Virology, vol. 83, no. 7, pp. 3094–3103, 2009.
- B. Hu, H. Yang, B. Dai, A. Tai, and P. Wang, “Nonintegrating lentiviral vectors can effectively deliver ovalbumin antigen for induction of antitumor immunity,” Human Gene Therapy, vol. 20, no. 12, pp. 1652–1664, 2009.
- Z. Michelini, D. R. M. Negri, S. Baroncelli, et al., “Development and use of SIV-based Integrase defective lentiviral vector for immunization,” Vaccine, vol. 27, no. 34, pp. 4622–4629, 2009.
- L. Naldini, U. Blomer, P. Gallay, et al., “In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector,” Science, vol. 272, no. 5259, pp. 263–267, 1996.
- R. Bona, M. Andreotti, V. Buffa, et al., “Development of a human immunodeficiency virus vector-based, single-cycle assay for evaluation of anti-integrase compounds,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 10, pp. 3407–3417, 2006.
- R. Weiss, “The search for human RNA tumor viruses,” in RNA Tumor Viruses, R. Weiss, N. Teich, H. Varmus, and J. Coffin, Eds., pp. 1205–1218, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, USA, 2nd edition, 1982.
- F. Di Rosa and R. Pabst, “The bone marrow: a nest for migratory memory T cells,” Trends in Immunology, vol. 26, no. 7, pp. 360–366, 2005.
- V. Appay, D. F. Nixon, S. M. Donahoe, et al., “HIV-specific CD T cells produce antiviral cytokines but are impaired in cytolytic function,” The Journal of Experimental Medicine, vol. 192, no. 1, pp. 63–75, 2000.
- M. B. Banasik and P. B. McCray Jr., “Integrase-defective lentiviral vectors: progress and applications,” Gene Therapy, vol. 17, no. 2, pp. 150–157, 2010.
- K. Wanisch and R. J. Yáñez-Muñoz, “Integration-deficient lentiviral vectors: a slow coming of age,” Molecular Therapy, vol. 17, no. 8, pp. 1316–1332, 2009.
- V. Appay, P. R. Dunbar, M. Callan, et al., “Memory CD T cells vary in differentiation phenotype in different persistent virus infections,” Nature Medicine, vol. 8, no. 4, pp. 379–385, 2002.
- A.-K. Roos, F. Eriksson, J. A. Timmons, et al., “Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment,” PLoS ONE, vol. 4, no. 9, article e7226, 2009.