Review Article

Mathematical Modeling: Bridging the Gap between Concept and Realization in Synthetic Biology

Table 1

Modeling techniques used in the case studies.

Case studyModel typesModeling techniques
DeterministicStochasticParameter estimationOptimizationSensitivity analysisBifurcation analysis

Case study IFung et al. [6]; designed a synthetic oscillator in E. coli. × × × × ×

Case study IIFriedland et al. [7]; developed synthetic counters in E. coli that can count up to two or three induction events. × × × ×

Case study IIIGuido et al. [8]; constructed regulatory networks by assembling simpler building blocks. × × × × ×