Development of Th1 Imprints to rBCG Expressing a Foreign Protein: Implications for Vaccination against HIV-1 and Diverse Influenza Strains

Figure 5

Serum antibody responses of mice to β-gal after immunization with different doses of rBCG by the i.d. route, and subsequent challenge with a high dose of rBCG by the same route. Mice were immunized initially with doses indicated below each graph with age-matched control mice receiving only challenge dose shown. After 16 weeks, all groups were challenged with 2 × 10⁷ rBCG given i.d. Serum was collected at the time the mice were killed, 16 weeks after the challenge. Open bars show IgG1 titers while black bars depict IgG2a titers.

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