Substance P Signaling Contributes to Granuloma Formation in <i>Taenia crassiceps</i> Infection, a Murine Model of Cysticercosis

<table>Quantitative levels of IL-6 in granulomas derived from<i> Taenia crassiceps</i>  infected, WT (<svg height="10.8125" id="M88" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 42.912498 10.8125" width="42.912498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
<g transform="translate(72,-63.35)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">2</tspan>
</text>
</g>
</g>
</svg>), SPP-knockout mice (<svg height="11.0375" id="M89" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">6</tspan>
</text>
</g>
</g>
</svg>), and NK1-knockout mice (<svg height="11.0375" id="M90" style="vertical-align:-0.27588pt" version="1.1" viewbox="0 0 35.099998 11.0375" width="35.099998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
<g transform="translate(72,-63.17)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">9</tspan>
</text>
</g>
</g>
</svg>). Data presented are mean <svg height="9.3249998" id="M91" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 10.825 9.3249998" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.325)">
<g transform="translate(72,-64.54)">
<text transform="matrix(1,0,0,-1,-71.95,65.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">±</tspan>
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</g>
</g>
</svg> SEM; *<svg height="11.25" id="M92" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 44.424999 11.25" width="44.424999" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">5</tspan>
</text>
</g>
</g>
</svg>, IL-6  levels in infected, SPP-knockout derived granulomas versus WT derived granulomas, <sup>†</sup><svg height="11.25" id="M93" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 48.337502 11.25" width="48.337502" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="26.056252" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">5</tspan>
</text>
</g>
</g>
</svg>,  IL-6  levels in infected, NK1-knockout derived granulomas versus WT derived granulomas.</table>

BioMed Research International

fig4

Figure 4

Figure 4: Substance P Signaling Contributes to Granuloma Formation in <i>Taenia crassiceps</i> Infection, a Murine Model of Cysticercosis 

BioMed Research International

Substance P Signaling Contributes to Granuloma Formation in Taenia crassiceps Infection, a Murine Model of Cysticercosis

Figure 4