Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model

Table 3

Effects of Drug Therapy on New Bone Density (mg/cc HA).

Treatment versus Blank	Group Size	Bone density (mg/cc HA; mean ± S.D.)		t-test
		Drug	Blank	𝑃 value
Empty Defect	5	998±52	1023±36	0.401
Low-Dose Alendronate	4	966±20	988±32	0.284
High-Dose Alendronate	5	975±42	1012±32	0.156
Low-Dose Lovastatin	6	1027±49	993±16	0.138
High-Dose Lovastatin	6	977±54	1016±45	0.200
Low-Dose Omperazole	6	1018±20	1006±38	0.487
High-Dose Omperazole	6	1003±22	1009±26	0.673