A Pivotal Role for Interleukin-27 in CD8<sup>+</sup> T Cell Functions and Generation of Cytotoxic T Lymphocytes

<table>IL-27 is a multifunctional cytokine that mainly activates both STAT1 and STAT3 together with STAT2, STAT4, and STAT5. IL-27 mediates its several biological functions by selectively utilizing these STAT1 and STAT3, which bind to distinct IL-27R subunits, IL-27R<i>α</i> and gp130, respectively. IL-27 acts on various types of cells including CD4<sup>+</sup> and CD8<sup>+</sup> T cells, B cells, NK cells, macrophages, mast cells, and endothelial cells.</table>

BioMed Research International

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Figure 2: A Pivotal Role for Interleukin-27 in CD8<sup>+</sup> T Cell Functions and Generation of Cytotoxic T Lymphocytes 

BioMed Research International

A Pivotal Role for Interleukin-27 in CD8+ T Cell Functions and Generation of Cytotoxic T Lymphocytes

Figure 2

A Pivotal Role for Interleukin-27 in CD8⁺ T Cell Functions and Generation of Cytotoxic T Lymphocytes