Research Article
Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice
Table 2
Effect of EDgP on formalin-induced licking in mice.
| Treatment | Dose | Paw licking (s) | | (mg/kg, i.p.) | Early phase (0–5 minutes) | Inhibition (%) | Late phase (15–30 minutes) | Inhibition (%) |
| Control (10 mL/kg i.p.) | | 85.8 ± 7.6 | | 233.9 ± 23.6 | | D. grandiflora | 75 | 46.6 ± 6.5* | 45.7 | 44.0 ± 27.5* | 81.2 | 150 | 35.5 ± 5.3* | 58.6 | 0.0 ± 0.0* | 100 | 300 | 43.5 ± 5.0* | 49.3 | 29.0 ± 27.9* | 87.6 | Morphine | 10 | 33.5 ± 4.6* | 61.0 | 60.7 ± 24.8* | 74.0 | Naloxone | 6 | | | | | + | | | | | | D. grandiflora | 300 | 47.1 ± 4.3* | 45.1 | 4.9 ± 4.9* | 97.9 | Morphine | 10 | 69.2 ± 8.0 | 19.3 | 246.3 ± 30.5 | 0 |
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Values are mean ± S.E.M. (). versus control, Bonferroni test.
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