Antinociceptive and Toxicological Effects of Dioclea grandiflora Seed Pod in Mice

Table 3

Effect of EDgP on the hot plate test in mice.

Treatment	Dose	Reaction time (s)
	(mg/kg, i.p.)	30 minutes	60 minutes	120 minutes
Control (10 mL/kg, i.p.)		7.2 ± 1.3	8.3 ± 1.1	6.5 ± 0.9
D. grandiflora	75	11.8 ± 2.8	10.7 ± 2.2	8.0 ± 1.3
	150	9.2 ± 1.6	11.8 ± 1.8	10.1 ± 1.7
	300	12.2 ± 1.8	10.0 ± 2.0	9.6 ± 1.6
Morphine	10	18.5 ± 2.5*	11.5 ± 0.8*	11.0 ± 1.7*

Values are mean ± S.E.M. (𝑛=10). ^∗𝑃<.05 versus control.