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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 609526, 11 pages
http://dx.doi.org/10.1155/2010/609526
Research Article

Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice

1Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan
2Department of Surgery, Buddhist Tzu Chi General Hospital, Taipei 231, Taiwan
3Graduate Institute of Disease Pvention and Control, Taipei Medical University, Taipei 110, Taiwan
4Department of Neurosurgery, Mackay Memorial Hospital, Taipei 104, Taiwan
5Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan
6Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei 110, Taiwan

Received 4 March 2010; Accepted 5 May 2010

Academic Editor: Thomas Griffith

Copyright © 2010 Po-An Tai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aims of the present paper were to ascertain whether the heat-induced ischemia and oxidative damage to the hypothalamus and lethality in mice could be ameliorated by hyperbaric oxygen therapy. When normobaric air-treated mice underwent heat treatment, the fractional survival and core temperature at 4 hours after heat stress were found to be 0 of 12 and 34C±0.3C, respectively. In hyperbaric oxygen-treated mice, when exposed to the same treatment, both fractional survival and core temperature values were significantly increased to new values of 12/12 and 37.3C±0.3C, respectively. Compared to normobaric air-treated heatstroke mice, hyperbaric oxygen-treated mice displayed lower hypothalamic values of cellular ischemia and damage markers, prooxidant enzymes, proinflammatory cytokines, inducible nitric oxide synthase-dependent nitric oxide, and neuronal damage score. The data indicate that hyperbaric oxygen may improve outcomes of heatstroke by normalization of hypothalamic and thermoregulatory function in mice.