Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice

Figure 2

Effects of heat exposure (42.4^∘C for 1 hour) on extracellular levels of glutamate, lactate-to-pyruvate ratio, glycerol, dihydroxybenzoic acid, and nitric oxide in the hypothalamus of normothermic mice received normobaric air (A), normothermic mice received hyperbaric oxygen (B), heatstroke mice received normobaric air (C), and heatstroke mice received hyperbaric oxygen (D). Bars are mean±SE of eight mice per group. Samples were obtained at 4 hours after the termination of 1-hour heat exposure or the equivalent time for the normothermic controls. ^∗𝑃<.01 compared with corresponding control values in group (A). ^†𝑃<.01 compared with corresponding values in group (C).