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Journal of Biomedicine and Biotechnology
Volume 2010 (2010), Article ID 623687, 12 pages
http://dx.doi.org/10.1155/2010/623687
Review Article

RNA Vaccines in Cancer Treatment

Department of Oncology and Hematology, University Hospital Bonn, 53111 Bonn, Germany

Received 23 December 2009; Accepted 22 March 2010

Academic Editor: Hanchun Yang

Copyright © 2010 Anita Bringmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Cancer Report from the World Health Organization states that in the year 2000 12% of all death cases worldwide were caused by cancer. In the western world, the cancer death rates are often devastating, being at about 25%. This fact stresses the urgency to find effective cures against malignant diseases. New approaches in the treatment of cancer focus on the development of immunotherapies to fight the disease. Besides other methods, the usage of tumor-specific RNA as part of vaccines is investigated lately. RNA, administered alone or used for transfection of dendritic cells, shows several advantages as a vaccine including feasibility, applicability, safeness, and effectiveness when it comes to the generation of immune responses. This review concentrates on results from in vitro experiments and recent trials using RNA vaccines to present an overview about this specific strategy.