Research Article
Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects
Table 4
Maternal MTHFR and CBS 844ins68 genotype combinations, Children’s Hospital of Philadelphia, 1997–2007.
| | | CBS 844ins68 | | | | II | IN | NN | P value |
| MTHFR genotypes | | | | | C677T | | | | | CC (%) | 4 (2.5) | 19 (11.8) | 138 (85.7) | | CT (%) | 0 | 31 (16.0) | 163 (84.0) | | TT (%) | 0 | 2 (3.6) | 54 (96.4) | .01 | A1298C | | | | | AA (%) | 1 (0.5) | 20 (10.2) | 175 (89.3) | | AC (%) | 1 (0.5) | 27 (14.9) | 153 (84.5) | | CC (%) | 2 (6.1) | 5 (15.2) | 26 (78.9) | .02 |
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