FSHR Single Nucleotide Polymorphism Frequencies in Proven Fathers and Infertile Men in Southeast Turkey

Table 2

Allele combinations considering the FSHR polymorphisms at −29 and codon 680, genotype distribution, and serum FSH levels (mean ± SE) in men with proven fathers and infertile (nonobstructive azoospermic and severe oligozoospermic). *The first three groups (1, 2, and 3) were combined as one group in the Chi-square test.

Group	Allele combination (−29/680)	Proven fathers		Nonobstructive azoospermic		Severe Oligozoospermic
		(𝑛=240)		(𝑛=150)		(𝑛=120)
		Frequency 𝑛 (%)	FSH (IU/I)	Frequency 𝑛 (%)	FSH (IU/I)	Frequency 𝑛 (%)	FSH (IU/I)
1*	A-Asn/A-Asn	8 (3.33)	3.1 ± 0.4	5 (3.33)	23.1 ± 1.9	4 (3.33)	11.3 ± 5.7
2*	A-Asn/A-Ser	2 (0.83)	2.9 ± 0.4	3 (2.00)	23.5 ± 1.9	1 (0.83)	12.5 ± 6.1
3*	A-Ser/A-Ser	2 (0.83)	3.0 ± 0.5	1 (0.67)	24.0 ± 2.0	1 (0.83)	12.7 ± 6.4
4	A-Asn/G-Asn	31 (12.92)	3.4 ± 0.3	17 (11.33)	22.4 ± 1.2	21 (17.50)	12.3 ± 6.8
5	A-Asn/G-ser or G-Asn/A-Ser	10 (4.17)	3.3 ± 0.3	8 (5.33)	22.8 ± 1.7	3 (2.50)	13.5 ± 7.2
6	A-Ser/G-Ser	7 (2.92)	3.4 ± 0.4	2 (1.33)	23.3 ± 1.3	6 (5.00)	13.6 ± 7.4
7	G-Asn/G-Asn	117 (48.75)	3.5 ± 0.4	73 (48.67)	21.5 ± 1.1	59 (49.17)	12.5 ± 5.5
8	G-Asn/G-Ser	36 (15.00)	3.3 ± 0.4	34 (22.67)	21.7 ± 1.3	8 (6.67)	13.7 ± 6.2
9	G-Ser/G-Ser	27 (11.25)	3.4 ± 0.4	7 (4.67)	22.4 ± 1.3	17 (14.17)	13.8 ± 6.0