A Metabolic Model of Human Erythrocytes: Practical Application of the E-Cell Simulation Environment

Figure 2

A Metabolic pathway map constructed using the E-Cell RBC model. The complete reaction network of the metabolism in the E-Cell RBC model. MgX/oxyHbX/deoxyHbX/band3X denotes the complex formed by compound “X” and Mg²⁺, oxyhemoglobin, deoxyhemoglobin, or band 3, respectively. Abbreviations used in this figure: GLC, glucose; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; F1,6-BP, fructose-1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; GA3P, glyceraldehyde-3-phosphate; 1,3-BPG, 1,3-bisphosphoglycerate; 2,3-BPG, 2,3-bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; LAC, lactate; GL6P, gluconolactone-6-phosphate; GO6P, gluconate-6-phosphate; RU5P, ribulose-5-phosphate; X5P, xylulose-5-phosphate; E4P, erythrose-4-phosphate; S7P, sedoheptulose-7-phosphate; R5P, ribose-5-phosphate; PRPP, 5-phosphoribosyl-1-phosphate; ADE, adenine; IMP, inosine monophosphate; R1P, ribose-1-phosphate; INO, inosine; ADO, adenosine; HX, hypoxanthine; AMP, adenosine monophosphate; ADP, adenosine diphosphate; ATP, adenosine triphosphate; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, nicotinamide adenine dinucleotide phosphate (reduced); NAD, nicotinamide adenine dinucleotide; NADH, nicotinamide adenine dinucleotide (reduced); Ki, potassium ion; Nai, Sodium ion; Pi, inorganic phosphate; L_GC, L-glutamyl cysteine; GSH, glutathione (reduced); GSSG, glutathione (oxidized).