The Role of Genetic Variation Near Interferon-Kappa in  Systemic Lupus Erythematosus

<table>Association analysis of imputed <i><i>IFNK </i></i> SNPs. Each symbol represents an SNP, with downward pointing triangles showing the SNPs directly genotyped and upward pointing triangles indicating the SNPs which were imputed (see methods for details of imputation). <svg height="10.325" id="M61" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.6125 10.325" width="11.6125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑌</tspan>
</text>
</g>
</g>
</svg>-axis shows the inverse log of the <svg height="10.325" id="M62" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
</text>
</g>
</g>
</svg> value resulting from the case-control chi-square test statistic for each SNP. <svg height="10.325" id="M63" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 13.4125 10.325" width="13.4125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑋</tspan>
</text>
</g>
</g>
</svg>-axis shows the location of each SNP in bases along chromosome 9. Each color represents a different ancestral background/sex included in this analysis. Due to low numbers, African-American (AA) males and Asian males were not included. EA: European ancestry, M: male, and F: female.</table>

BioMed Research International

fig3

Figure 3

Figure 3: The Role of Genetic Variation Near Interferon-Kappa in  Systemic Lupus Erythematosus 