The Role of Genetic Variation Near Interferon-Kappa in Systemic Lupus Erythematosus

Table 4

SNPs in the IFNK locus which demonstrate evidence for association with SLE following stratification by sex in each ancestral background.

SNP (ancestry)	MA	Females				Males
		Cases	Cont	OR (95% CI)	𝑃	Cases	Cont	OR (95% CI)	𝑃
rs1977661 (EA)	A	0.101	0.117	0.85 (0.74–0.98)	.023	0.080	0.109	0.69 (0.48–0.99)	.047
rs12553951 (EA)	C	0.074	0.072	1.04 (0.88–1.23)	.62	0.107	0.060	1.93 (1.36–2.74)	.00025
rs3861016 (EA)	C	0.067	0.078	0.85 (0.72–1.00)	.05	0.056	0.071	0.75 (0.49–1.16)	.20
rs2814707 (AA)	A	0.195	0.235	0.79 (0.65–0.96)	.020	0.204	0.229	0.85 (0.51–1.40)	.52

EA: European ancestry, AA: African-American ancestry, MA: minor allele, “Case” and “Cont”: allele frequency of the minor allele in cases and controls respectively, OR: odds ratio, 95% CI = 95% confidence interval of the odds ratio, 𝑃 = 𝑃 value.